PMID: 7023450Aug 1, 1981Paper

Prevention of wound infection in elective colorectal resections by preoperative cephazolin with and without metronidazole

The Australian and New Zealand Journal of Surgery
F T McDermottE S Hughes

Abstract

Fifty patients were admitted to a prospective controlled double blind trial for assessment of the effect of preoperative intramuscular cephazolin with oral metronidazole or placebo on the incidence of wound infection in patients requiring treatment by elective large intestinal resection. All patients were operated upon by one surgeon. After exclusion of two patients who died postoperatively 48 were analysed. No wound infection occurred in 22 patients receiving cephazolin with metronidazole. One (3.8%) infection developed in 26 patients receiving cephazolin with placebo. The difference did not attain statistical significance. Preoperative intramuscular cephazolin with or without metronidazole provides an effective and safe method of chemoprophylaxis for elective colorectal resection.

Citations

Mar 1, 1982·World Journal of Surgery·E S HughesE A Pihl
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Feb 21, 2008·Journal of Psychosocial Oncology·Terry A CronanRuth Gallagher
Nov 1, 1986·American Journal of Surgery·J T DiPiroJ A Mansberger
Dec 29, 2004·The Annals of Thoracic Surgery·Orjan FribergJan Källman
Nov 13, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Changhua ChenBaoyuan Chen
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
May 1, 1987·Drug Intelligence & Clinical Pharmacy·L Danziger, E Hassan
Feb 1, 1983·Current Problems in Surgery·J T DipiroW O Griffen

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