PMID: 2507341Sep 1, 1989Paper

Prevention or moderation of some ultrastructural changes in the RPE and retina of galactosemic rats by aldose reductase inhibition

Experimental Eye Research
S A Vinores, P A Campochiaro

Abstract

Rats were maintained on a 50% galactose diet with and without the aldose reductase inhibitor, Sorbinil, or on a normal diet of rat chow, and the retinas and retinal pigment epithelium were examined ultrastructurally at time points ranging from 4 weeks to 20 months. Several ultrastructural changes were observed in the retinal pigment epithelium and retinal capillaries of galactosemic rats that were not seen in rats on a normal diet. Only some of these changes are similar to those that have been previously noted in diabetic (glucosemic) rats. As in diabetics, galactosemic rats demonstrated thickening of the basal laminae of the retinal pigment epithelium and retinal capillaries. They also manifested vacuolization and degenerative foci in the retinal pigment epithelium that were similar, but not identical, to changes seen in diabetic rats. Each of these changes was significantly inhibited by Sorbinil. Unlike diabetics, galactosemic rats did not have dilated basal infoldings, but did have outer retinal folds and a significant increase in large-lipofuscin-like aggregates in the retinal pigment epithelium, both of which were partly prevented by Sorbinil. These data suggest that multiple mechanisms may be involved in retinal and retin...Continue Reading

References

Oct 1, 1979·Archives of Ophthalmology·G H BresnickG de Venecia
May 1, 1978·Archives of Ophthalmology·T KrupinB Becker
May 1, 1978·Archives of Ophthalmology·S WaltmanB Becker
Nov 1, 1975·The British Journal of Ophthalmology·J Cunha-VazA J Campos
Jan 1, 1986·Drugs·W G RobisonP F Kador
Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R Poulsom, B Hayes
Aug 15, 1986·American Journal of Ophthalmology·B MillerS J Ryan
Oct 1, 1985·Current Eye Research·A A SimaP K Basu
Jul 1, 1984·Annals of Internal Medicine·D G CoganC Kupfer
Feb 1, 1984·Experimental Eye Research·M L Katz, W G Robison
Aug 1, 1981·Experimental Eye Research·T S Kern, R L Engerman

❮ Previous
Next ❯

Citations

Jul 1, 1995·Diabetes/metabolism Reviews·R L Engerman, T S Kern
Sep 11, 1999·Neurochemistry International·R Salceda
Mar 21, 2008·Neurochemical Research·Rocío SalcedaGustavo Sánchez-Chávez
Sep 28, 2010·Progress in Retinal and Eye Research·Chung-Jung Chiu, Allen Taylor
Feb 14, 2006·Neurochemical Research·Víctor CoffeRocío Salceda
Feb 16, 2008·Neurochemical Research·Gustavo Sánchez-ChávezRocío Salceda
Mar 17, 2009·Experimental Eye Research·Ingeborg KlaassenReinier O Schlingemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.