Preventive and therapeutic role of Tanshinone ⅡA in hepatology

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Miao-Juan ShiHui Zhang

Abstract

Liver diseases cause serious public health problems because of their high global prevalence and poor long-term clinical outcomes. With its mild and broad therapeutic efficacy, traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of liver diseases in China for hundreds of years. Tanshinone IIA (TIIA), a major component extracted from the traditional herbal medicine Salvia miltiorrhiza Bunge, has been broadly studied for its multiple biological activities, including antiangiogenic, antioxidant, anti-inflammatory and anticancer properties. In this article, we focus on the effects of TIIA on the development of liver diseases, including hepatic injury, fatty liver, hepatic fibrosis and hepatocellular carcinoma (HCC), as well as the mechanism underlying TIIA and its new formulations and carriers in order to provide a reference for its further study and clinical therapeutic use in liver diseases.

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Citations

Apr 24, 2020·Oxidative Medicine and Cellular Longevity·Weiwei ChenWeiqin Li
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinping HeChang Li
Jan 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qingji YingZhanxiong Xue
Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoqi PanCheng Peng
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhangyang BiWei Zhang
Oct 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ningning YangShizhu Jin
Oct 12, 2021·Frontiers in Medicine·Thit Mynster KronborgNina Kimer

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