Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria

Intensive Care Medicine
Matteo BassettiGaryphallia Poulakou

Abstract

The antibiotic pipeline continues to diminish and the majority of the public remains unaware of this critical situation. The cause of the decline of antibiotic development is multifactorial and currently most ICUs are confronted with the challenge of multidrug-resistant organisms. Antimicrobial multidrug resistance is expanding all over the world, with extreme and pandrug resistance being increasingly encountered, especially in healthcare-associated infections in large highly specialized hospitals. Antibiotic stewardship for critically ill patients translated into the implementation of specific guidelines, largely promoted by the Surviving Sepsis Campaign, targeted at education to optimize choice, dosage, and duration of antibiotics in order to improve outcomes and reduce the development of resistance. Inappropriate antimicrobial therapy, meaning the selection of an antibiotic to which the causative pathogen is resistant, is a consistent predictor of poor outcomes in septic patients. Therefore, pharmacokinetically/pharmacodynamically optimized dosing regimens should be given to all patients empirically and, once the pathogen and susceptibility are known, local stewardship practices may be employed on the basis of clinical respo...Continue Reading

References

Dec 18, 2001·Chest·P Eggimann, D Pittet
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha ApisarnthanarakLinda M Mundy
Mar 24, 2005·Intensive Care Medicine·José Garnacho-MonteroF J Jiménez-Jiménez
Feb 8, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K GoethaertH Goossens
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy H DellitUNKNOWN Society for Healthcare Epidemiology of America
Aug 31, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F DrobniewskiUNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobi
Nov 17, 2007·Nature Reviews. Microbiology·Lenie DijkshoornHarald Seifert
Dec 11, 2007·American Journal of Infection Control·Jane D SiegelUNKNOWN Health Care Infection Control Practices Advisory Committee
Dec 14, 2007·The Journal of Antimicrobial Chemotherapy·Neil Woodford
Dec 20, 2007·Critical Care Medicine·Daren K HeylandUNKNOWN Canadian Critical Care Trials Group
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad SpellbergUNKNOWN Infectious Diseases Society of America
Oct 23, 1948·Lancet·M BARBER, M ROZWADOWSKA-DOWZENKO
Nov 4, 2008·International Journal of Antimicrobial Agents·Emanuele Durante-MangoniMatthew E Falagas
May 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bjorn L HerpersEdward J Kuijper
Aug 22, 2009·Chest·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock Database Research Group
Aug 22, 2009·American Journal of Respiratory and Critical Care Medicine·Ricard FerrerUNKNOWN Edusepsis Study Group
Nov 11, 2009·The Journal of Antimicrobial Chemotherapy·M SundqvistG Kahlmeter
Dec 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesús Rodríguez-BañoUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)
Dec 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Charles-Edouard LuytJean Chastre
Jan 16, 2010·Journal of Critical Care·Jan J De WaeleDirk Vogelaers
Mar 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Infectious Diseases Society of America
May 1, 2010·Current Medical Research and Opinion·J Floris S LogmanBen A van Hout
Jun 10, 2010·JAMA : the Journal of the American Medical Association·Miguel Sánchez GarcíaJuan Picazo
Jul 20, 2010·Critical Care Medicine·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
Apr 1, 2011·The New England Journal of Medicine·Yves LongtinDidier Pittet
Apr 5, 2011·The Journal of Antimicrobial Chemotherapy·Reham KakiNick Daneman
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 2, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G SamonisM E Falagas
Oct 12, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Rodríguez-BañoUNKNOWN ESBL-REIPI Group
Nov 22, 2011·The Lancet Infectious Diseases·Laura J V Piddock
Jan 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard G WunderinkJean Chastre
Mar 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lidia DalfinoNicola Brienza
Apr 3, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paritosh PrasadCharles Natanson

❮ Previous
Next ❯

Citations

Oct 23, 2015·Expert Review of Anti-infective Therapy·Ligia S C F RabelloJorge If Salluh
Dec 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marin H Kollef, Scott T Micek
Jan 14, 2016·Virulence·Matteo BassettiAlessia Carnelutti
Feb 3, 2016·The Journal of Antimicrobial Chemotherapy·Alexandre BrasseurFabio Silvio Taccone
Jan 23, 2016·Intensive Care Medicine·Heleen M Oudemans-van Straaten, Jean-Jacques Parienti
Feb 13, 2016·Current Opinion in Infectious Diseases·Matteo BassettiAlessia Carnelutti
Mar 31, 2016·The New England Journal of Medicine·Paul YoungRichard Beasley
Nov 14, 2015·Intensive Care Medicine·François BarbierSaad Nseir
Apr 5, 2016·Intensive Care Medicine·Matteo BassettiJean-François Timsit
Aug 21, 2015·Intensive Care Medicine·J J De WaeleG Dimopoulos
Aug 12, 2015·Annals of Intensive Care·Étienne RuppéFrançois Barbier
Jun 17, 2015·Intensive Care Medicine·Cédric BretonnièreUNKNOWN Société Française d’Anesthésie et de Réanimation (SFAR)
Apr 20, 2016·Intensive Care Medicine·François BarbierMarc J M Bonten
May 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jean-Louis VincentMassimo Antonelli
Jun 12, 2016·Bioorganic & Medicinal Chemistry Letters·Frédéric BrunelMichel Camplo
Jul 23, 2016·International Journal of Antimicrobial Agents·Sheng-Feng HuangYing-Chi Lin
Jul 2, 2016·Current Infectious Disease Reports·Jan J De Waele
Jul 31, 2016·American Journal of Infection Control·Abdulmajeed Ghanem KraiemKhalifa Sifaw Ghenghesh
Aug 10, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P GarcinuñoJ C Rodríguez
Jul 28, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G LedouxS Nseir
Oct 1, 2016·Intensive Care Medicine·Dominique D BenoitJean-Francois Timsit
Oct 8, 2016·Annals of Intensive Care·Gabor ZilahiIgnacio Martin-Loeches
Sep 21, 2016·Intensive Care Medicine·François Barbier, Charles-Edouard Luyt
Dec 7, 2016·Expert Review of Anti-infective Therapy·G PoulakouG Dimopoulos
Jan 13, 2017·Current Opinion in Infectious Diseases·Katerina KazianiGeorge Dimopoulos
Mar 8, 2017·Expert Review of Clinical Pharmacology·Antonio Gutiérrez-PizarrayaIgnacio Martin-Loeches
Aug 25, 2017·Expert Review of Clinical Pharmacology·José Garnacho-MonteroMarin H Kollef
Sep 14, 2017·Intensive Care Medicine·Matteo BassettiGaryphallia Poulakou
Aug 16, 2017·Qualitative Health Research·Letizia Caronia, Marzia Saglietti
Sep 13, 2018·Expert Review of Anti-infective Therapy·Matteo BassettiAlessandro Russo
Dec 17, 2015·Antimicrobial Agents and Chemotherapy·Simon PoignantFrançois Barbier
Dec 7, 2018·Current Opinion in Infectious Diseases·José Garnacho-Montero, Jean-François Timsit
Dec 26, 2018·Expert Review of Anti-infective Therapy·Matteo BassettiFrancesco Curcio
Jul 12, 2018·Minerva anestesiologica·Giorgia MontrucchioLuca Brazzi
Jan 24, 2019·Expert Review of Anti-infective Therapy·Jan J De Waele, Sofie Dhaese
Feb 14, 2018·The European Respiratory Journal·Anne-Sophie MoreauUNKNOWN TAVeM Study Group
Sep 9, 2017·Epidemiology and Infection·L JiangM I Chen
Oct 13, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Ralph ZaharFrançois Barbier
Jul 25, 2019·Current Opinion in Critical Care·Rosario Amaya-Villar, José Garnacho-Montero

❮ Previous
Next ❯

Software Mentioned

MAXSEPT
IDSA
COMBACTE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Intensive Care Medicine
Maureen Campion, Gail Scully
Current Pharmaceutical Biotechnology
Marjolein P D Deege, David L Paterson
South Dakota Medicine : the Journal of the South Dakota State Medical Association
M Azhar Gangat, Jennifer L Hsu
© 2021 Meta ULC. All rights reserved