Preventive Antibiotics for Poststroke Infection in Patients With Acute Stroke: A Systematic Review and Meta-analysis

The Neurologist
Xiaonian HanLi Ma

Abstract

To determine if preventive antibiotics is effective in poststroke infection in patients with acute stroke in comparison with no prophylaxis. MEDLINE (1950 to January 2017), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 1, 2017) and EMBASE (1974 to January 2017) databases were used to search for randomized controlled trials with intervening measures related to the preventive antibiotics in patients with acute stroke. Besides, the reference lists of the retrieved publications were manually searched to explore other relevant studies. We included 6 randomized controlled trials involving 4110 stroke patients. The study population, study design, intervening measures, and definition of infection were different. Preventive antibiotics significantly reduced the incidence of algorithm-defined infection in patients with acute stroke from 11.14% (220/1975) to 7.43% (149/2006); odds ratio (OR)=0.41; 95% confidence interval (CI), 0.20-0.87; P=0.02. There was no difference in mortality between 2 groups, the mortality in preventive antibiotics group was 17.03% (347/2037) and control group was 16.10% (328/2037); OR=1.07; 95% CI, 0.90-1.27; P=0.44. And preventive antibiotics did not improve the proporti...Continue Reading

References

Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·A ChamorroJ Mensa
May 31, 2007·Neurology·I L KatzanR D Cebul
Mar 15, 2008·Lancet Neurology·Hedley C A Emsley, Stephen J Hopkins
May 15, 2008·Cerebrovascular Diseases·UNKNOWN European Stroke Organisation (ESO) Executive Committee, UNKNOWN ESO Writing Committee
Aug 14, 2009·Expert Review of Neurotherapeutics·Shinji Teramoto
Sep 16, 2009·Archives of Neurology·Diederik van de BeekPaul J Nederkoorn
Sep 22, 2011·BMC Neurology·Willeke F WestendorpDiederik van de Beek
Jan 10, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Richard D Wilson
Mar 13, 2012·Neurology India·M V Padma SrivastavaManjiri Tripathi
Jun 6, 2013·Cerebrovascular Diseases·Yousef HannawiEric M Bershad
Jul 23, 2013·Stroke; a Journal of Cerebral Circulation·Edith KohlerDavid Blacker
Apr 1, 2011·The Neurohospitalist·John R Armstrong, Benjamin D Mosher
Nov 15, 2014·Stroke; a Journal of Cerebral Circulation·Gitta RohwederBent Indredavik
Jun 27, 2015·Stroke; a Journal of Cerebral Circulation·Craig J SmithAndreas Meisel
Jan 3, 2016·European Journal of Internal Medicine·Alejandro BustamanteJoan Montaner
Jan 8, 2016·International Journal of Molecular Sciences·Raymond Shim, Connie H Y Wong
May 29, 2016·Journal of Neuroimmunology·Kyra J BeckerShawn Skerrett
Jul 20, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Lalit KalraUNKNOWN STROKE-INF Investigators

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Fengcai ShenYiyu Deng
The Cochrane Database of Systematic Reviews
Jan-Dirk VermeijPaul J Nederkoorn
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
A H MomsenJ S Lindholt
International Clinical Psychopharmacology
Yan ChenSiyan Zhan
© 2022 Meta ULC. All rights reserved