Abstract
To determine if preventive antibiotics is effective in poststroke infection in patients with acute stroke in comparison with no prophylaxis. MEDLINE (1950 to January 2017), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 1, 2017) and EMBASE (1974 to January 2017) databases were used to search for randomized controlled trials with intervening measures related to the preventive antibiotics in patients with acute stroke. Besides, the reference lists of the retrieved publications were manually searched to explore other relevant studies. We included 6 randomized controlled trials involving 4110 stroke patients. The study population, study design, intervening measures, and definition of infection were different. Preventive antibiotics significantly reduced the incidence of algorithm-defined infection in patients with acute stroke from 11.14% (220/1975) to 7.43% (149/2006); odds ratio (OR)=0.41; 95% confidence interval (CI), 0.20-0.87; P=0.02. There was no difference in mortality between 2 groups, the mortality in preventive antibiotics group was 17.03% (347/2037) and control group was 16.10% (328/2037); OR=1.07; 95% CI, 0.90-1.27; P=0.44. And preventive antibiotics did not improve the proporti...Continue Reading
References
Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·A ChamorroJ Mensa
May 31, 2007·Neurology·I L KatzanR D Cebul
Oct 3, 2007·Neurology·Y LamplM Sadeh
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Stefan SchwarzMichael G Hennerici
Mar 15, 2008·Lancet Neurology·Hedley C A Emsley, Stephen J Hopkins
May 15, 2008·Cerebrovascular Diseases·UNKNOWN European Stroke Organisation (ESO) Executive Committee, UNKNOWN ESO Writing Committee
May 15, 2008·PloS One·Hendrik HarmsAndreas Meisel
Aug 30, 2008·Neuroscience·J KlehmetC Meisel
Aug 14, 2009·Expert Review of Neurotherapeutics·Shinji Teramoto
Sep 16, 2009·Archives of Neurology·Diederik van de BeekPaul J Nederkoorn
Sep 22, 2011·BMC Neurology·Willeke F WestendorpDiederik van de Beek
Jan 10, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Richard D Wilson
Mar 13, 2012·Neurology India·M V Padma SrivastavaManjiri Tripathi
Sep 18, 2012·Advances in Therapy·Yukito Shinohara, Hideki Origasa
Feb 2, 2013·Stroke; a Journal of Cerebral Circulation·Edward C JauchUNKNOWN Council on Clinical Cardiology
Jun 6, 2013·Cerebrovascular Diseases·Yousef HannawiEric M Bershad
Jul 23, 2013·Stroke; a Journal of Cerebral Circulation·Edith KohlerDavid Blacker
Apr 1, 2011·The Neurohospitalist·John R Armstrong, Benjamin D Mosher
Nov 15, 2014·Stroke; a Journal of Cerebral Circulation·Gitta RohwederBent Indredavik
Jan 24, 2015·Lancet·Willeke F WestendorpUNKNOWN PASS investigators
Jun 27, 2015·Stroke; a Journal of Cerebral Circulation·Craig J SmithAndreas Meisel
Sep 8, 2015·Lancet·Lalit KalraUNKNOWN STROKE-INF Investigators
Jan 3, 2016·European Journal of Internal Medicine·Alejandro BustamanteJoan Montaner
Jan 8, 2016·International Journal of Molecular Sciences·Raymond Shim, Connie H Y Wong
May 25, 2016·Internal and Emergency Medicine·Konstantinos TziomalosApostolos I Hatzitolios
May 29, 2016·Journal of Neuroimmunology·Kyra J BeckerShawn Skerrett
Jun 24, 2016·Cerebrovascular Diseases·Jan-Dirk VermeijUNKNOWN PASS Investigators
Jul 20, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Lalit KalraUNKNOWN STROKE-INF Investigators