Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts

Journal of Biochemical and Molecular Toxicology
Radhiga ThangaiyanRajendra Prasad Nagarajan

Abstract

We investigated the effect of apigenin, a dietary flavonoid, on isoproterenol hydrochloride (ISO)-induced apoptotic signaling in cardiomyoblast H9C2 cells. The results showed that apigenin treatment (10 µM) prevented ISO (31.25 μM)-induced lipid peroxidative levels and antioxidants status in H9C2 cells. Furthermore, apigenin inhibited expression of inflammatory markers in ISO-treated cells. In addition, apigenin prevented ISO-induced DNA damage and apoptotic signaling through modulating the expression of Bax, caspase-3, -8 and -9, cytochrome c, and Fas proteins in H9C2 cells. It is concluded that apigenin prevents ISO-induced antioxidants depletion, oxidative DNA damage, inflammatory, and apoptotic signaling in H9C2 cells. Thus, the present results demonstrated that apigenin has a cardioprotective effect on cardiomyoblasts cells.

References

Sep 1, 1991·Mutation Research·E A MartinsR Meneghini
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Oct 17, 1968·European Journal of Biochemistry·W G Niehaus, B Samuelsson
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jan 1, 1994·Methods in Cell Biology·Z DarzynkiewiczJ Gong
Jan 27, 2000·Phytochemistry·A BasileR C Cobianchi
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Mar 30, 2002·General Pharmacology·Y H ZhangY P Yun
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jun 1, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sushma M BhosleKaushala Prasad Mishra
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Anita S GálvezGuillermo Díaz-Araya
Oct 21, 2006·Archives of Biochemistry and Biophysics·Kazuki KanazawaTakashi Hashimoto
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yumei YeYochai Birnbaum
Jun 25, 2009·European Journal of Pharmacology·Bi-hui JinQiang Xia
Mar 30, 2011·International Immunopharmacology·Megumi Funakoshi-TagoTadashi Kasahara
Jul 22, 2011·Journal of Signal Transduction·Parthiv AminKrishna Singh
Dec 23, 2011·Cell Death & Disease·M ChiongS Lavandero
Feb 1, 2012·Biochimie·Thangaiyan RadhigaKodukkur Viswanathan Pugalendi
Oct 15, 2013·Microbiology and Immunology·Gloria Gutiérrez-VenegasCristina Hernández-Bermúdez
Nov 8, 2014·Cardiovascular Toxicology·Jing HuZheng-Ping Jia
Feb 27, 2016·The American Journal of Chinese Medicine·Yu-Lan YehChih-Yang Huang
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kapil SuchalDharamvir Singh Arya
Apr 5, 2017·International Journal of Molecular Sciences·Umesh B MahajanSameer N Goyal
Jul 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun YangDong-Lin Chen

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Citations

Aug 23, 2020·Biomedicines·Shoib Sarwar SiddiquiCijo George Vazhappilly
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Darija Šarić MustapićMirza Bojić
Dec 18, 2020·Frontiers in Pharmacology·Radhiga ThangaiyanNagarajan Rajendra Prasad

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis