PMID: 9659353Jul 11, 1998Paper

Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats

Thorax
A AzumaS Kudoh

Abstract

Erythromycin has been reported to have an inhibitory effect on chronic inflammatory airway disease and chronic infiltration of neutrophils into the airway. Bleomycin (BLM) often induces interstitial lung fibrosis following acute lung injury. A study was undertaken to investigate the effects of erythromycin (EM) on experimental bleomycin-induced acute lung injury in rats. Bleomycin-induced lung injury was assessed by light microscopic examination, measurement of neutrophil elastase activity and of the interleukin 8 (IL-8) content in bronchoalveolar lavage (BAL) fluid. The potential inhibitory effect of erythromycin was assessed by overall comparison of erythromycin untreated (BLM alone), concurrently treated (BLM + EM), and pretreated (BLM + pre-EM) groups. The neutrophil count and concentration of neutrophil-derived elastase in BAL fluid were significantly different in the three groups. The morphological changes of lung injury were also less extensive in rats pretreated with erythromycin. However, these protective effects were not marked in the group concurrently treated with erythromycin. Moreover, the concentration of IL-8 in the BAL fluid tended to be less in the erythromycin treated groups; however, there were no significan...Continue Reading

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Citations

Nov 29, 2012·General Thoracic and Cardiovascular Surgery·Atsushi WatanabeTetsuya Higami
Apr 9, 2005·The Journal of Antibiotics·Kiminari YoshidaSatoshi Omura
Jan 25, 2005·British Journal of Pharmacology·María-Jesús SanzEsteban J Morcillo
Apr 12, 2003·Critical Care Medicine·Theo J MoraesGregory P Downey
Jul 9, 2010·Clinical Microbiology Reviews·Soichiro Kanoh, Bruce K Rubin
Jun 4, 2011·Pulmonary Medicine·Atsushi WatanabeTetsuya Higami
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·G BorzoneC Lisboa
Nov 26, 2011·Chest·Allan J Walkey, Renda S Wiener
Jan 25, 2016·Journal of Critical Care·Majid AfsharEllen L Burnham
Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb

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