Preventive effect of gamma-glutamylcysteinylethyl ester on carbon tetrachloride-induced hepatic triglyceride accumulation in mice

Toxicology Letters
K NishidaI Ishiguro

Abstract

The effect of gamma-glutamylcysteinylethyl ester (gamma-GCE), which is a precursor of reduced glutathione (GSH), on carbon tetrachloride (CCl4)-induced hepatic triglyceride (TG) accumulation in mice was investigated in comparison with that of GSH. Administration of gamma-GCE (160 micromol/kg), but not GSH (160 micromol/kg), to mice at 3 h after CCl4 injection (1 ml/kg, i.p.) significantly attenuated an increase in hepatic TG concentration at 6, 12, and 24 h after the CCl4 injection. A decrease in hepatic GSH concentration after the CCl4 injection was significantly diminished by the gamma-GCE administration, but not by the GSH administration. The correlation coefficient between hepatic TG concentration and hepatic GSH concentration was -0.627 (P < 0.001) when the results of all mice were grouped together. These results indicate that gamma-GCE can attenuate CCl4-induced hepatic TG accumulation in mice through the maintenance of hepatic GSH level.

References

Jan 1, 1990·Annual Review of Pharmacology and Toxicology·D J Reed
Sep 1, 1969·Biochemical Pharmacology·G Ugazio, M V Torrielli
Nov 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·M J Fletcher
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·C G Crafton, N R DiLuzio
Aug 21, 1996·Biochimica Et Biophysica Acta·K NishidaI Ishiguro
Jun 17, 1960·Biochimica Et Biophysica Acta·M C SCHOTZ, R O RECKNAGEL

❮ Previous
Next ❯

Citations

Jul 8, 2008·Bioscience, Biotechnology, and Biochemistry·Yusi ZhouYoung-Sun Song
Feb 24, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jinn-Tsyy LaiWen-Chuan Lin
May 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Yu HungGow-Chin Yen
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivana CacciatoreAntonio Di Stefano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.