Abstract
The effect of weekly treatments with various gammaglobulin preparations on the development of human B-cell tumors was studied in severe combined immunodeficient (SCID) mice. SCID mice were injected i.p. with human peripheral blood mononuclear cells (PBMCs) from an Epstein-Barr virus (EBV)-seropositive healthy blood donor. Repopulated SCID mice were divided into 7 treatment groups receiving either PBS, 2 commercial gammaglobulin preparations, purified IgG prepared from pooled plasma from EBV-seronegative or -seropositive blood donors, a rabbit anti-serum against EBV envelope glycoprotein gp340 or interferon (IFN)-alpha. All treatments started 1 day after injection of PBMC and continued for 8 weeks. In the PBS-treated control group, 85% of mice developed tumors in the abdominal cavity, mostly with liver metastasis within 150 days. Tumor formation was prevented by treatment with the 2 commercial gammaglobulin preparations as well as by purified IgG from EBV-seropositive donors. In contrast, purified IgG from EBV-seronegative donors, rabbit anti-gp340 anti-serum or IFN-alpha had no effect. Our results indicate that the effect of gammaglobulin is due to the presence of specific antibodies against EBV antigens. Further experiments sh...Continue Reading
References
Feb 1, 1992·The Journal of General Virology·S FinertyA J Morgan
Mar 1, 1992·European Journal of Immunology·M R AbediC I Smith
Jul 1, 1992·The Journal of Experimental Medicine·R J MurrayA B Rickinson
Sep 1, 1992·The Journal of Clinical Investigation·A DurandyA Fischer
Jan 1, 1992·Vaccine·M MadejM Mackett
Jun 28, 1991·Cell·S HendersonA Rickinson
May 1, 1990·The Journal of Infectious Diseases·A LindeB Wahren
Mar 11, 1989·Lancet·S J Hamilton-DutoitC Pedersen
Sep 15, 1988·Nature·D E MosierD B Wilson
May 1, 1985·Transplantation·D W HantoR L Simmons
Feb 1, 1987·Journal of Medical Virology·A LindeB Wahren
Aug 1, 1984·Journal of Virology·S FennewaldE Kieff
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HennessyE Kieff
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D A Thorley-Lawson, K Geilinger
Feb 10, 1983·Nature·G C BosmaM J Bosma
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·M R AbediC I Smith
May 4, 1995·International Journal of Cancer. Journal International Du Cancer·A E MilnerC D Gregory
Mar 10, 1995·Cell·T BluntS P Jackson
Apr 28, 1994·The New England Journal of Medicine·E B PapadopoulosT N Small
Aug 14, 1993·Lancet·P CinqueA Linde
Sep 1, 1995·Medicinal Research Reviews·G C ViscomiS Silvestri
Citations
Dec 18, 2013·Bone Marrow Transplantation·M UhlinM Remberger
Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M GreenD Rowe
Sep 24, 2013·Haematologica·Michael UhlinJonas Mattsson
Jul 19, 2008·Annals of Hematology·R TrappeS Oertel
Mar 3, 2007·The Lancet Oncology·Gerhard OpelzBernd Döhler
Jun 6, 2008·American Journal of Hematology·Shernan G HoltanSvetomir N Markovic
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GreenJ Reyes
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Green, M G Michaels
Jul 22, 2014·Pediatric Transplantation·L Ramirez-AvilaJ D Cherry
Jan 9, 2004·Pediatric Clinics of North America·Michael Green, Steven Webber
Apr 10, 2003·Journal of Medical Virology·Erik VerschuurenT Hauw The
Apr 7, 2015·The Journal of Allergy and Clinical Immunology·Omar K AlkhairyLennart Hammarström
Aug 9, 2003·Expert Opinion on Drug Safety·Yaniv ShererYehuda Shoenfeld
Aug 15, 2002·Transplantation·Ronald D HolmesRonald J Sokol
Sep 6, 2000·Transplantation·M GreenJ Reyes
Jun 28, 2018·European Journal of Haematology·Yuhua RuDepei Wu
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S C Deresinski
Mar 30, 2006·Transplantation·Atul HumarUpton Allen
Feb 1, 2013·Transplantation·Peter JakschWalter Klepetko
Dec 10, 1999·Transplantation·C V PayaJ S Bromberg
May 16, 2019·Bone Marrow Transplantation·Rama Al HamedMohamad Mohty
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·In-Jeong KimMarcia A Blackman