PMID: 9178818May 16, 1997Paper

Preventive effect of IgG from EBV-seropositive donors on the development of human lympho-proliferative disease in SCID mice

International Journal of Cancer. Journal International Du Cancer
M R AbediC I Smith

Abstract

The effect of weekly treatments with various gammaglobulin preparations on the development of human B-cell tumors was studied in severe combined immunodeficient (SCID) mice. SCID mice were injected i.p. with human peripheral blood mononuclear cells (PBMCs) from an Epstein-Barr virus (EBV)-seropositive healthy blood donor. Repopulated SCID mice were divided into 7 treatment groups receiving either PBS, 2 commercial gammaglobulin preparations, purified IgG prepared from pooled plasma from EBV-seronegative or -seropositive blood donors, a rabbit anti-serum against EBV envelope glycoprotein gp340 or interferon (IFN)-alpha. All treatments started 1 day after injection of PBMC and continued for 8 weeks. In the PBS-treated control group, 85% of mice developed tumors in the abdominal cavity, mostly with liver metastasis within 150 days. Tumor formation was prevented by treatment with the 2 commercial gammaglobulin preparations as well as by purified IgG from EBV-seropositive donors. In contrast, purified IgG from EBV-seronegative donors, rabbit anti-gp340 anti-serum or IFN-alpha had no effect. Our results indicate that the effect of gammaglobulin is due to the presence of specific antibodies against EBV antigens. Further experiments sh...Continue Reading

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Citations

Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GreenJ Reyes
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Green, M G Michaels
Jan 9, 2004·Pediatric Clinics of North America·Michael Green, Steven Webber
Apr 7, 2015·The Journal of Allergy and Clinical Immunology·Omar K AlkhairyLennart Hammarström
Aug 9, 2003·Expert Opinion on Drug Safety·Yaniv ShererYehuda Shoenfeld
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S C Deresinski
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·In-Jeong KimMarcia A Blackman

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