Preventive effect of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation

Clinical Nutrition ESPEN
Mohammad MohammadiMohammad Alidoosti

Abstract

Oxidative stress plays an important role in platelet activation and endothelial dysfunction. Exogenous and endogenous reactive oxygen species are associated with platelet activation and vascular dysfunction. Antioxidants have been shown to attenuate oxidative stress and consequently endothelial dysfunction by preventing inflammation, regulating vascular tone, and promoting antiadhesive and antithrombotic properties. l-carnitine and its derivatives have been demonstrated to improve endothelial and platelet function against oxidative stress by several mechanisms, some of which cannot be found in other antioxidants. The role of l-carnitine and its derivatives in endothelial dysfunction and platelet activation will be reviewed here from the perspective of basic and clinical research. This study reviews in vitro and in vivo studies, clinical trials, and abstracts in the English language that have examined the protective effects of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation in pathological conditions. We searched experimental studies, clinical trials, and other review articles to obtain the materials. Although in vitro physiological models, animal studies on vascular and platelet function, and...Continue Reading

Citations

Oct 23, 2019·Oxidative Medicine and Cellular Longevity·Robert Antoni OlekWieslawa Lysiak-Szydlowska
May 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra DurazzoAntonello Santini
Dec 22, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Giovanni PaganoMarco Trifuoggi
Jul 18, 2018·Journal of Agricultural and Food Chemistry·Luigi ServilloMaria Luisa Balestrieri

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