Preventive effect of Lactobacillus reuteri CRL1324 on Group B Streptococcus vaginal colonization in an experimental mouse model

Journal of Applied Microbiology
Priscilla Romina De GregorioMaría Elena Fátima Nader-Macías

Abstract

To assess the preventive effect of different intravaginal (i.va.) doses of Lactobacillus reuteri CRL1324 against vaginal colonization by Group B Streptococcus (GBS) in a murine experimental model. The major virulence factors of four vaginal GBS clinical isolates were determined to select the most virulent strain and set up a murine model of streptococcal vaginal colonization. Later, the effect of four and seven doses of 10(8) viable cells of Lact. reuteri CRL1324 i.va. administered, prior to the GBS challenge was studied. Seven doses of lactobacilli were able to significantly reduce the number of viable GBS cells, while four doses showed no preventive effect. Both doses reduced the leucocyte influx induced by GBS. Seven doses caused a slight increase in the Lact. reuteri CRL1324 vaginal colonization compared with four doses and reduced murine vaginal pH compared to control mice. Lactobacillus reuteri CRL1324 evidenced a preventive effect on GBS vaginal colonization in an experimental mouse model. Maternal GBS colonization is one of the most important risk factors for developing disease in newborns. Lactobacillus reuteri CRL1324 could be considered as a new biological agent to reduce infections caused by this micro-organism.

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Citations

Nov 9, 2015·American Journal of Reproductive Immunology : AJRI·Priscilla Romina De GregorioMaría Elena Fátima Nader-Macías
Aug 25, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·María Silvina Juárez TomásMaría Elena Fátima Nader-Macías
Nov 19, 2015·Journal of Clinical Pathology·Alessandro Di CerboTommaso Iannitti
Apr 11, 2015·Advanced Drug Delivery Reviews·María Elena Fátima Nader-Macías, María Silvina Juárez Tomás
May 6, 2016·Archives of Microbiology·María Cecilia Leccese TerrafMaría Elena Fátima Nader-Macías
Sep 22, 2017·The Journal of Infectious Diseases·Geoffrey H RosenAdam J Ratner
Dec 7, 2017·Frontiers in Immunology·Julia Kolter, Philipp Henneke
Jun 17, 2015·Infection and Immunity·Kathryn A PatrasKelly S Doran
Jan 29, 2019·FEMS Yeast Research·Priscilla Romina De GregorioMaría Elena Fátima Nader-Macías
Jun 20, 2020·Microbial Cell Factories·Priscilla Romina De GregorioBeatrice Vitali
Feb 19, 2020·Current Pharmaceutical Design·Antonella MarchesiMaría E F Nader-Macías
Nov 14, 2020·Scientific Reports·Alex FarrLjubomir Petricevic
Oct 6, 2021·Pharmacology Research & Perspectives·María Elena Fátima Nader-MacíasJessica Alejandra Silva

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