Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells

Cancer Detection and Prevention
Y FukeT Nomura

Abstract

Effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) or a 6-MITC-containing T-wasabi fraction from wasabi root (Wasabia japonica Matsum) to inhibit the macroscopic pulmonary metastasis was studied with a murine B16-BL6 melanoma model. Two administration routes, subcutaneous or intravenous, and two administration times, prior to or concomitant with tumor inoculation, of 6-MITC or T-wasabi against the metastatic foci formation in C57BL/6J mouse lungs were compared. The number of metastasized foci per lung in either subcutaneous or intravenous injection was significantly reduced by intake of 6-MITC or a T-wasabi fraction. The maximum reduction by a T-wasabi fraction reached to 82%. Fifty-six percent of foci formation was inhibited by a 2 week-prior administration of 6-MITC (200 microM), whereas only 27% inhibition was obtained by a concomitant administration with tumor inoculation. Neither 6-MITC nor T-wasabi at tested concentrations showed any toxic effects. Together with our previous results, a component of the Japanese pungent spice, wasabi appears to inhibit not only tumor cell growth but also tumor metastasis. Therefore, 6-MITC from wasabi is apparently a useful dietary candidate for controlling tu...Continue Reading

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Citations

Jun 14, 2013·Journal of Natural Medicines·Takayuki OkamotoKoji Suzuki
Mar 24, 2011·Pigment Cell & Melanoma Research·Deeba N Syed, Hasan Mukhtar
Nov 3, 2010·Clinics in Dermatology·J Daniel JensenRobert P Dellavalle
Feb 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Jen ChenHui-Fen Liao
Apr 21, 2019·Antioxidants·Melina MitsiogianniMihalis I Panayiotidis

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