Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model

American Journal of Obstetrics and Gynecology
Akitoshi HasegawaAtsuko Kato

Abstract

Lactoferrin, an iron-binding glycoprotein found in cervical mucus and amniotic fluid, plays a defensive role against mucosal infections. This study examined the effect of recombinant human lactoferrin on preterm delivery in a rabbit model. Anesthetized rabbits were randomly assigned to receive either inoculation with Escherichia coli or saline solution and to receive treatment with or without recombinant human lactoferrin inserted into the cervix 2 hours before bacterial inoculation (condition A: saline + saline; condition B: E coli + saline; condition C: E coli + recombinant human lactoferrin). E coli , saline solution, and recombinant human lactoferrin were inserted into the cervix using a hysteroscope and a sterile polyethylene cannula. Fetus survival rate and days to delivery after inoculation were monitored and tumor necrosis factor-alpha concentrations were measured in maternal serum and amniotic fluid. Fetus survival for conditions A, B, and C were 95.7%, 0%, and 32.6%, respectively, whereas pregnancy continuation was 7.00 +/- 0 days, 3.25 +/- 0.43 days, and 4.85 +/- 1.77 days, respectively. Cervical recombinant human lactoferrin administration increased fetal survival and extended pregnancy. Lactoferrin has an anti-infl...Continue Reading

References

Jan 15, 1992·FEMS Microbiology Letters·T SoukkaM Lenander-Lumikari
Dec 1, 1990·American Journal of Obstetrics and Gynecology·R A DombroskiRonald S Gibbs
Oct 1, 1989·British Journal of Obstetrics and Gynaecology·J Drife
Mar 1, 1993·American Journal of Obstetrics and Gynecology·N T FieldW A Peairs
Nov 1, 1996·Obstetrics and Gynecology·N KagaY Shibutani
Feb 12, 1998·Journal of Reproductive Immunology·D J Dudley
Apr 9, 1999·Placenta·K OtsukiT Yanaihara
Jul 5, 2003·Placenta·J A KeelanM D Mitchell

Citations

Jan 6, 2009·Journal of Negative Results in Biomedicine·Emmet HirschRoberto Romero
Mar 1, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M LocciG De Placido
Apr 28, 2006·The Journal of Pharmacy and Pharmacology·Eugene D Weinberg
Nov 18, 2008·The Journal of Obstetrics and Gynaecology Research·Ken NakayamaTakashi Okai
Jan 13, 2015·Annals of Clinical and Translational Neurology·Yohan van de LooijStéphane V Sizonenko
Nov 16, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·S C LouxB A Ball
Jan 14, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Theresa J Ochoa, Stéphane V Sizonenko
Feb 1, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Katsufumi Otsuki, Noriaki Imai
Sep 30, 2017·Microbial Ecology in Health and Disease·Alessandra PinoAntonio Cianci
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan F Mitchell, Michael J Taggart

Related Concepts

Escherichia Coli Infections
Fetal Mummification
Preterm Premature Rupture of Fetal Membranes
Immunocytochemistry
Premature Obstetric Labor
Lactoferrin
Placenta
Pregnancy, Animal
Primary Prevention
Randomization

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