Preventive effect of regional radiotherapy with phosphorus-32 glass microspheres in hepatocellular carcinoma recurrence after hepatectomy.

World Journal of Gastroenterology : WJG
Xiao-Ming WangGuo-Yang Wu

Abstract

To evaluate the preventive effects of phosphorus-32 glass microspheres (P32-GMS) in the recurrence of massive hepatocellular carcinomas (HCCs) after tumor resection. Twenty-nine patients with massive HCCs received local P32-GMS implantation after liver tumors were removed, while the other 38 patients with massive HCCs were not treated with P32-GMS after hepatectomies. The radioactivity of the blood, urine and liver were examined. The complications, HCC recurrence and overall survival rates in the patients were analyzed. P32-GMS implanted in the liver did not cause systemic absorption of P32. There were no significant differences of postoperative complications between the patients with and without P32-GMS treatment. The short-term (six months and 1 year) and long-term (2, 3 and over 3 years) recurrence rates in patients who received P32-GMS radiotherapy were significantly decreased, and the overall survival rates in this group were significantly improved. P32-GMS implantation in the liver can significantly decrease the postoperative recurrence and improve the overall survival in HCCs patients after hepatectomy. This therapy may provide an innovative method in prevention of HCC recurrence after operation.

References

Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShirabeK Sugimachi
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MatsumataK Sugimachi
Jan 1, 1995·World Journal of Surgery·S KawasakiK Nishimaki
Jan 1, 1995·American Journal of Surgery·J N VautheyM Brennan
Jan 1, 1996·Archives of Surgery·K TakenakaK Sugimachi
Dec 1, 1995·Surgical Endoscopy·M HashizumeK Sugimachi
Jun 1, 1996·The British Journal of Surgery·J BalsellsC Margarit
Sep 1, 1996·The British Journal of Surgery·J YamamotoM Makuuchi
Jan 1, 1996·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·A ToyosakaK Miura
Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Apr 11, 2000·Journal of the American College of Surgeons·Y SugawaraM Makuuchi
Dec 2, 2000·Journal of Gastroenterology and Hepatology·Z Y Tang
Mar 26, 2003·Journal of Gastroenterology and Hepatology·Philip Chong-Hei KwokWai Ming Lam
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eveline BoucherJean-Luc Raoul
Mar 3, 2004·Journal of the American College of Surgeons·Nobuhiko Shimozawa, Kazuhiro Hanazaki
May 27, 2004·World Journal of Gastroenterology : WJG·Dong-Sheng ZhangQun-Hui Li
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kai ZhangPierce K H Chow
Mar 28, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Boudewijn BransCornelis Punt
Dec 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Anthony Soon-Whatt GohPierce Kah-Hoe Chow
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Del GaudioA D Pinna

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Citations

Mar 13, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiao-Dong WangBin Li
Dec 7, 2010·Indian Journal of Cancer·M S Rajput, P Agrawal
Dec 25, 2009·Cancer Treatment Reviews·Shumei MaXiaodong Liu
Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masakazu KawashitaHiroyasu Kanetaka
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Carin F GonsalvesBrian I Carr
Dec 19, 2008·Expert Review of Gastroenterology & Hepatology·Maria PleguezueloAndrew K Burroughs
Jan 1, 2020·Cancers·Sue Anne ChewSerena Danti
Jul 31, 2020·Nature Reviews. Drug Discovery·George SgourosJessie R Nedrow

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