Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury

The Journal of Pharmacy and Pharmacology
T Sangeetha, S Darlin Quine

Abstract

The present study was designed to evaluate the preventive effect of S-allyl cysteine sulfoxide (SACS) in isoproterenol (ISO)-induced myocardial ischaemia in male Wistar rats. Rats were pretreated with SACS (40 and 80 mg kg(-1) body-weight) for 5 weeks. After the treatment period, ISO (150 mg kg(-1) body-weight) was administered subcutaneously to rats at intervals of 24 h for 2 days. The activities of creatine kinase, creatine kinase-MB, lactate dehydrogenase, aspartate transaminase and alanine transferase were significantly increased in serum and significantly decreased in the hearts of ISO-treated rats. Pretreatment with SACS decreased the activities of these enzymes significantly in serum and significantly increased the activities in heart in ISO-treated rats. The levels of cholesterol, triglycerides and free fatty acids increased in serum and heart, while the levels of phospholipids increased in serum and decreased in heart in ISO-treated rats. SACS pretreatment showed a significant effect on the lipids studied. The activity of 3-hydroxy 3-methyl glutaryl coenzyme A (HMG CoA) reductase was significantly increased and the activity of lecithin cholesterol acyl transferase (LCAT) was significantly reduced in ISO-induced rats. O...Continue Reading

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Citations

Jun 2, 2009·Critical Reviews in Food Science and Nutrition·Masood Sadiq ButtJavaid Iqbal
Sep 9, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rachel M Novick, Adnan A Elfarra
May 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abhro Jyoti Roy, P Stanely Mainzen Prince
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Tarak Nath KhatuaSanjay K Banerjee
Dec 13, 2006·Cancer·Sherry Salway BlackMary Jackson Scroggins
Jul 17, 2018·Phytotherapy Research : PTR·Prince AllawadhiChandraiah Godugu
Jul 30, 2019·Journal of Food Biochemistry·Cheng ZhangXichun Peng

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