Preventive effect of Vitamin B supplementation on recurrent stroke: a Meta-analysis

Zhonghua wei zhong bing ji jiu yi xue
Guining DaiZengning Li

Abstract

To evaluate whether Vitamin B supplementation could prevent ischemic stroke recurrence. Randomized controlled trials (RCTs) observing Vitamin B supplementation in patients with stroke was performed in databases including ScienceDirect, PubMed/Medline, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, Wanfang Database, and VIP Chinese Science and Technology Journal Database to find related studies in English or Chinese published before August 2016. The patients in control group received a placebo or basic therapy without Vitamin B, and those in experimental group was treated with Vitamin B alone or Vitamin B on the basis of conventional treatment. The data were collected by two researchers independently and the quality of studies was assessed by the modified Jadad Scale. The Meta-analysis was performed using Stata 12.0, funnel plot was drawn, and Egger and Begg regressions were used to evaluate the publication bias, and sensitivity was also analyzed. Seven RCTs studies were enrolled to analyze with a total number of 9 846 stroke patients, 4 755 patients in control group, and 5 091 in experimental group, respectively. (1) Vitamin B supplementation for prevention of recurrent stroke: heterogeneity test results...Continue Reading

Citations

Mar 17, 2021·Critical Reviews in Food Science and Nutrition·Geir BjørklundBeatrice Severin

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