Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis

The Journal of Pharmacy and Pharmacology
Jia-Jia WangYing-Ying Chen

Abstract

The study was to investigate the prevention effects and possible mechanism of Yu Ping Feng San fractioned polysaccharide (YPF-P) on CCl(4)-induced liver fibrosis in rats. YPF-P was prepared from root of Astragalus membranaceus, rhizome of Atractylodes macrocephaia and root of Raidix saposhnikoviae, and compared with polysaccharide from root of Astragalus membranaceus (AP). Hepatic fibrosis was induced by subcutaneous injection with carbon tetrachloride twice weekly for 12 weeks in Sprague-Dawley rats. YPF-P, AP and colchicine were administered intragastrically daily to carbon tetrachloride-treated rats. Histopathological changes of the liver and hepatic stellate cells were evaluated by Masson staining and transmission electron microscopy, respectively. Markers of fibrosis were determined by radioimmunoassay, biochemistry assay and ELISA. The mRNA expressions of tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-13 (MMP-13), procollagen I and collagen III were detected by RT-PCR. YPF-P dose-dependently alleviated the degree of liver fibrosis and inhibited hepatic stellate cell transformation into myofibroblast-like cells, markedly reduced the elevated levels of hyaluronic acid, laminin, type IV collagen, ...Continue Reading

References

Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W ChenA Kirn
Oct 1, 1994·Pathology, Research and Practice·M J Arthur
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P IredaleG Murphy
Dec 2, 1998·Journal of Hepatology·E Olaso, S L Friedman
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I ShimizuS Ito
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·S D Shapiro, R M Senior
Jul 27, 1999·The Journal of Biological Chemistry·H Nagase, J F Woessner
Mar 23, 2000·Journal of Hepatology·D A BrennerR A Rippe
Oct 7, 2000·Journal of Gastroenterology·J Wu, M A Zern
May 7, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Leonie BeljaarsKlaas Poelstra
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hitoshi YoshijiHiroshi Fukui
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Jan 20, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Xingjun LiuJames Q Yin
May 16, 2006·Digestive Diseases·Andrew J Fowell, John P Iredale
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroshi UchinamiJeanine D'Armiento
Oct 31, 2006·Journal of Biotechnology·Xia WangPing Xu
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·John M LukSheung-Tat Fan
Nov 3, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Satoshi HagiwaraMasatomo Mori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.