Preventive Effects of Bee Venom Derived Phospholipase A₂ on Oxaliplatin-Induced Neuropathic Pain in Mice

Toxins
Dong Xing LiSun Kwang Kim

Abstract

Oxaliplatin, a chemotherapy drug used to treat colorectal cancer, induces specific sensory neurotoxicity signs that are aggravated by cold and mechanical stimuli. Here we examined the preventive effects of Bee Venom (BV) derived phospholipase A₂ (bvPLA₂) on oxaliplatin-induced neuropathic pain in mice and its immunological mechanism. The cold and mechanical allodynia signs were evaluated by acetone and von Frey hair test on the hind paw, respectively. The most significant allodynia signs were observed at three days after an injection of oxaliplatin (6 mg/kg, i.p.) and then decreased gradually to a normal level on days 7-9. The oxaliplatin injection also induced infiltration of macrophages and upregulated levels of the pro-inflammatory cytokine interleukin (IL)-1β in the lumbar dorsal root ganglia (DRG). Daily treatment with bvPLA₂ (0.2 mg/kg, i.p.) for five consecutive days prior to the oxaliplatin injection markedly inhibited the development of cold and mechanical allodynia, and suppressed infiltration of macrophages and the increase of IL-1β level in the DRG. Such preventive effects of bvPLA₂ were completely blocked by depleting regulatory T cells (Tregs) with CD25 antibody pre-treatments. These results suggest that bvPLA₂ ma...Continue Reading

References

Nov 1, 1992·British Journal of Pharmacology·F Q CunhaS H Ferreira
Aug 15, 1994·Brain Research·L R WatkinsS F Maier
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M Armstrong, G Cota
Aug 11, 2001·Journal of Neuroimmunology·J C CoprayH W Boddeke
Apr 17, 2002·Journal of Neurology·Stefan Quasthoff, Hans Peter Hartung
Jun 7, 2002·Critical Reviews in Oncology/hematology·Bernard Desoize, Claudie Madoulet
Nov 8, 2002·Seminars in Oncology·Jim Cassidy, Jean-Louis Misset
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Hongxia Zhao, Paavo K J Kinnunen
Mar 27, 2003·Nature Reviews. Immunology·Jeffrey A Bluestone, Abul K Abbas
Jun 5, 2003·Expert Opinion on Pharmacotherapy·Jörg Thomas Hartmann, Hans-Peter Lipp
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Catherine AbbadieMichael J Forrest
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
May 4, 2006·Chembiochem : a European Journal of Chemical Biology·Maria Chiara MontiLuigi Gomez-Paloma
Aug 15, 2006·Immunological Reviews·Shimon SakaguchiTakashi Nomura
Dec 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans-Joachim SchmollDaniel G Haller
Apr 12, 2007·International Anesthesiology Clinics·Jun-Ming Zhang, Jianxiong An
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Dec 14, 2007·Journal of Neuroimmunology·Richard A O'Connor, Stephen M Anderton
Jun 24, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sherry WolfCharles Loprinzi
Aug 14, 2008·The Annals of Pharmacotherapy·Shilpa Amara
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benoit BarretteSteve Lacroix
Feb 24, 2009·The Journal of Pain : Official Journal of the American Pain Society·Elizabeth K Joseph, Jon D Levine
Aug 6, 2009·Handbook of Experimental Pharmacology·Richard J MillerFletcher A White
Oct 12, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lisa A KottschadeCharles L Loprinzi
Feb 19, 2011·Current Oncology·T Alcindor, N Beauger
Jul 12, 2011·Brain Research·Cristina Fabiola Kim, Gila Moalem-Taylor
Aug 5, 2011·Clinical Pharmacology and Therapeutics·D R PachmanC L Loprinzi
Aug 31, 2011·PloS One·Keisuke ShibataSchuichi Koizumi
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hyunseong KimHyunsu Bae

❮ Previous
Next ❯

Citations

Jan 21, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Justin G LeesGila Moalem-Taylor
Jan 10, 2018·Toxins·Vanessa O ZambelliYara Cury
Jun 18, 2017·Frontiers in Molecular Neuroscience·Hana Starobova, Irina Vetter
Feb 13, 2021·International Journal of Molecular Sciences·Takehiro KawashiriTakao Shimazoe
May 8, 2021·Neuroscience Letters·Megan L UhelskiPatrick M Dougherty
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
flow cytometry
Enzyme-Linked Immunosorbent Assay

Software Mentioned

Prism
GraphPad
SOFT max PRO

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.