Preventive effects of C-2 epimeric isomers of tea catechins on mouse type I allergy

Journal of Nutritional Science and Vitaminology
K YoshinoM Sano

Abstract

The preventive effects of C-2 epimeric isomers of (-)-epigallocatechin-3-O-gallate (EGCG) and the O-methylated derivative, (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3''Me), against ovalbumin-induced type I allergy in male mice were investigated. EGCG and EGCG3''Me exhibited strong antiallergic effects by oral administration at doses of 25 and 50 mg/kg body weight. The antiallergic effects of their C-2 epimers, (-)-gallocatechin-3-O-gallate and (-)-gallocatechin-3-O-(3-O-methyl)gallate (GCG3''Me), on mouse type I allergy were almost equivalent to and/or as strong as those of the corresponding original catechins, respectively. Oral administration of these compounds at a dose of 50 mg/kg body weight tended to suppress the increases in interleukin-4 levels in the abdominal walls of allergic mice and immunoglobulin E levels in the serum of allergic mice. In particular, the administration of GCG3''Me exhibited significant effects on the production and/or release of these parameters stimulating type 2 T helper cells and mast cells in the type I allergic process. These results indicated that C-2 epimerization of tea catechins, which are produced during heat processing at high temperatures, would not be disadvantageous for preve...Continue Reading

References

May 1, 1995·Biological & Pharmaceutical Bulletin·Y OhmoriH Konishi
Dec 20, 1999·Journal of Agricultural and Food Chemistry·M SanoM Maeda-Yamamoto
Mar 29, 2000·Bioscience, Biotechnology, and Biochemistry·H TachibanaK Yamada
Feb 15, 2001·Journal of Agricultural and Food Chemistry·Z ChenY Huang
Jul 22, 2004·Journal of Agricultural and Food Chemistry·Kyoji YoshinoMitsuaki Sano

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Citations

Oct 4, 2013·Biological & Pharmaceutical Bulletin·Yukihiro OritaniTatsuhiko Ito
Aug 5, 2016·Journal of Natural Medicines·Yeong-Seon WonHirofumi Tachibana
Sep 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshinori FujimuraHirofumi Tachibana
Nov 27, 2020·Food & Function·Qing-Sheng LiJian-Liang Lu

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