Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats.

Lipids in Health and Disease
Ying Qin, Ya-ping Tian

Abstract

Non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, can be reversed by early treatment. Several case reports have indicated that the administration of recombinant growth hormone (GH) could improve fatty liver in GH-deficient patients. Here, we investigated whether chronic exogenous GH levels could improve hepatic steatosis induced by a high-fat diet in rats, and explored the underlying mechanisms. High-fat diet-fed rats developed abdominal obesity, fatty liver and insulin resistance. Chronic exogenous GH improved fatty liver, by reversing dyslipidaemia, fat accumulation and insulin resistance. Exogenous GH also reduced serum tumour necrosis factor-alpha (TNF-alpha) levels, and ameliorated hepatic lipid peroxidation and oxidative stress. Hepatic fat deposition was also reduced by exogenous GH levels, as was the expression of adipocyte-derived adipokines (adiponectin, leptin and resistin), which might improve lipid metabolism and hepatic steatosis. Exogenous GH seems to improve fatty liver by reducing fat weight, improving insulin sensitivity and correcting oxidative stress, which may be achieved through phosphorylation or dephosphorylation of a group of signal transducers and activators of hep...Continue Reading

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Citations

Apr 15, 2011·Lipids in Health and Disease·Essam M HamadMahmoud Abdel-Hamid
Mar 13, 2008·PloS One·Anita M HennigeNorbert Stefan
Apr 2, 2015·International Journal of Food Sciences and Nutrition·Elisa V MacriSilvia M Friedman
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Sep 30, 2016·Diabetes·Zhongbo LiuShoshana Yakar
Jan 27, 2017·Clinical and Translational Gastroenterology·Laura E DichtelKaren K Miller
Jun 29, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ajay C DonepudiJohn Y L Chiang

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Methods Mentioned

BETA
MDA
light microscopy
antisense oligonucleotide
PCR
dot blot
enzyme-linked immunosorbent assay
electrophoresis

Software Mentioned

Image
Pro Plus
SPSS

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