Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model

Cancer Prevention Research
Holly L NicastroRonald A Lubet

Abstract

Urinary bladder cancer prevention studies were performed with the nonsteroidal anti-inflammatory drugs (NSAID) naproxen (a standard NSAID with a good cardiovascular profile), sulindac, and their nitric oxide (NO) derivatives. In addition, the effects of the ornithine decarboxylase inhibitor, difluoromethylornithine (DFMO), alone or combined with a suboptimal dose of naproxen or sulindac was examined. Agents were evaluated at their human equivalent doses (HED), as well as at lower doses. In the hydroxybutyl(butyl)nitrosamine (OH-BBN) model of urinary bladder cancer, naproxen (400 or 75 ppm) and sulindac (400 ppm) reduced the incidence of large bladder cancers by 82%, 68%, and 44%, respectively, when the agents were initially given 3 months after the final dose of the carcinogen; microscopic cancers already existed. NO-naproxen was highly effective, whereas NO-sulindac was inactive. To further compare naproxen and NO-naproxen, we examined their effects on gene expression in rat livers following a 7-day exposure. Limited, but similar, gene expression changes in the liver were induced by both agents, implying that the primary effects of both are mediated by the parent NSAID. When agents were initiated 2 weeks after the last adminis...Continue Reading

References

May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Sep 1, 2006·Circulation·Scott D SolomonUNKNOWN APC and PreSAP Trial Investigators
Sep 1, 2006·The New England Journal of Medicine·Monica M BertagnolliUNKNOWN APC Study Investigators
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Konstantin ChristovRonald A Lubet
Apr 2, 2008·Circulation·Scott D SolomonUNKNOWN Cross Trial Safety Assessment Group
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chun-Qi LiGerald N Wogan
Dec 1, 2010·Journal of the National Cancer Institute·Craig A ElmetsGary B Gordon
Jul 23, 2011·Cancer Prevention Research·Susan M FischerRonald A Lubet

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Citations

Jan 14, 2020·Prostaglandins & Other Lipid Mediators·Benjamin L WoolbrightJohn A Taylor

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