Preventive effects of rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury

Biological & Pharmaceutical Bulletin
Yuto AokiKunio Ishii

Abstract

Inhibitors of the mammalian target of rapamycin (mTOR) have been shown to protect against neuronal injury, but the mechanisms underlying this effect are not fully understood. The present study aimed to examine the effects of rapamycin, an inhibitor of the mTOR pathway, on inflammation and capillary degeneration in a rat model of N-methyl-D-aspartate (NMDA)-induced retinal neurotoxicity. Inflammation and capillary degeneration were evaluated by counting the numbers of CD45-positive leukocytes and Iba1-positive microglia, and by measuring the length of empty basement membrane sleeves, respectively. Marked increases in the numbers of leukocytes and microglia were observed 1 d after intravitreal injection of NMDA (200 nmol), and significant capillary degeneration was observed after 7 d. These NMDA-induced changes were significantly reduced by the simultaneous injection of rapamycin (20 nmol) with NMDA. These results suggest that rapamycin has preventive effects on inflammation and capillary degeneration during retinal injury.

References

Apr 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T T LamM O Tso
Dec 2, 2000·Science·D J Klionsky, S D Emr
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B RaughtN Sonenberg
Feb 3, 2006·Clinical & Experimental Ophthalmology·Robert J Casson
Feb 7, 2006·Neuroscience Research·Min-Lin ChangChen-Yuan Wen
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Ling ZhengTimothy S Kern
Feb 3, 2007·Journal of Neurochemistry·Toru NakazawaKohji Nishida
Feb 3, 2007·Neurobiology of Disease·S ErlichR Pinkas-Kramarski
Sep 19, 2009·Seminars in Immunopathology·Lisa Walter, Harald Neumann
Jul 24, 2010·The American Journal of Pathology·Mohammed M H Al-GayyarAzza B El-Remessy
Aug 31, 2010·Neuroscience Letters·Kaori UedaKunio Ishii
Oct 21, 2010·Physiological Reviews·Brinda RavikumarDavid C Rubinsztein
Mar 26, 2011·British Journal of Pharmacology·Mohammed M H Al-GayyarAzza B El-Remessy
Jun 28, 2011·Cell Death and Differentiation·N Rodríguez-MuelaP Boya
Jan 26, 2012·Neurobiology of Disease·Marco LeibingerDietmar Fischer
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
May 15, 2012·Current Diabetes Reports·Cristina Hernández, Rafael Simó
Oct 6, 2012·Current Opinion in Pharmacology·Rossella RussoMaria Tiziana Corasaniti
Dec 5, 2012·Biological & Pharmaceutical Bulletin·Yo TsudaKunio Ishii
Dec 12, 2012·European Journal of Pharmacology·Kaori UedaKunio Ishii
Feb 11, 2014·Journal of Neuroscience Research·Atsuko IchikawaKunio Ishii

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Citations

Nov 3, 2015·Biological & Pharmaceutical Bulletin·Ikumi HayashiKunio Ishii
Jul 3, 2016·Fundamental & Clinical Pharmacology·Ikumi HayashiKunio Ishii
Feb 2, 2017·Journal of Neuroinflammation·Soraya Wilke SalibaAntonio Carlos Pinheiro de Oliveira
Mar 26, 2021·Tissue Engineering. Part a·Ahad M SiddiquiNicolas N Madigan
May 1, 2021·International Journal of Molecular Sciences·Koki WatanabeTsutomu Nakahara

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