Preventive effects of Rhizoma Coptidis and Atractylodes on mice with gastric-ulcer

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Silu YouSha Liu

Abstract

To detemine preventive effects of compound formula Rhizoma Coptidis and Atractylodes on mice with gastric-ulcer. The mice were randomly divided into a normal group, a gastric ulcer group, a ranitidine positive drug group, a Rhizoma Coptidis group, an Atractylodes group, and a Rhizoma Coptidis plus Atractylodes group (the ratios of Coptidis to Atractylodes were 9꞉1, 8꞉2, 7꞉3, 6꞉4, 5꞉5, or 4꞉6, respectively). Gastric ulcer models were established by intragastric administration of anhydrous ethanol after 6 days of preventive infusion. The mice were killed 6 days after the treatments. The whole stomach was opened to observe gross morphology of gastric mucosa. The pathological changes of gastric tissue were observed under microscope, and serum samples were collected to detect the contents of superoxide dimutase (SOD), malondialdehyde (MDA), NO, and endothelin-1 (ET-1). The Rhizoma Coptidis and Atractylodes decoction significantly decreased ulcer area (P<0.001), and the effects of compound formula are better than those of Coptidis and Atractylodes alone (P<0.05, P<0.01, or P<0.001). The anti-ulcer effect of compound formula (Coptidis꞉Atractylodes=6꞉4) was the best one, and the anti-gastric ulcer effect of the high-dose group was sign...Continue Reading

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