Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries

European Journal of Pharmacology
H MasunagaK Higashio

Abstract

The effects of a naturally occurring deleted form of hepatocyte growth factor (HGF) on hepatic disorder were studied in various models of hepatic failure. The pretreatment of rats and mice with the deleted form of HGF prevented the liver injuries and coagulopathy induced by endotoxin, dimethylnitrosamine and acetaminophen and reduced the mortality due to hepatic dysfunction induced by these hepatotoxins. The concurrent administration of the deleted form of HGF also prevented the liver injury and hepatic fibrosis in mice treated with alpha-naphthylisothiocyanate and in rats treated with dimethylnitrosamine. Moreover, the deleted form of HGF normalized the results of the bromosulphalein-clearance test and ameliorated jaundice in rats with periportal cholangiolitic hepatopathy induced by alpha-naphthylisothiocyanate. The deleted form of HGF also reversed the coagulopathy in rats with hepatic disorder induced by dimethylnitrosamine or by 70% resection of cirrhotic liver (induced by carbon tetrachloride). In Long Evans cinnamon rats receiving vehicle, 20 out of 21 animals died within 4 days after the onset of jaundice. After infusion of the deleted form of HGF for 4 days, 7 out of 20 Long-Evans cinnamon rats survived. These results ...Continue Reading

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Citations

Oct 7, 2006·Current Opinion in Gastroenterology·R J Fontana
May 1, 2007·Regenerative Medicine·Shinya Mizuno, Toshikazu Nakamura
May 31, 2001·Kidney International·K Matsumoto, T Nakamura
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Jan 8, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akio IdoHirohito Tsubouchi
Jun 19, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anuradha KrishnanMichael Charlton
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Dec 19, 2008·Expert Review of Gastroenterology & Hepatology·Zahra Ghiassi-Nejad, Scott L Friedman

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