Preventive efficacy of NexGard Spectra® against Dipylidium caninum infection in dogs using a natural flea (Ctenocephalides felis) infestation model

Parasite : Journal De La Société Française De Parasitologie
Frederic BeugnetDiane Larsen

Abstract

The efficacy of a monthly oral endectocide product, NexGard Spectra® (Merial), a combination of afoxolaner and milbemycin oxime, was evaluated in a flea (Ctenocephalides felis) challenge model for the prevention of Dipylidium caninum tapeworm infection in dogs. The efficacy of treatment with NexGard Spectra® was assessed in 10 dogs following weekly flea infestation with metacestode naturally infected fleas and compared with that in 10 untreated control dogs. The 100 fleas deposited weekly on each dog were not removed until Day 35, allowing enough time for their ingestion. The microscopical analysis of 30 fleas from the flea batches before each weekly challenge demonstrated that 10-33% of the fleas were infected by D. caninum cysticercoid larvae. The arithmetic mean flea count recorded was 47.7 for the 10 untreated dogs and 0 for the 10 treated dogs at Day 35. Based on the daily collection of expelled D. caninum proglottids by dogs during the 70 days of the study, 70% (7/10) of the control dogs and 0% (0/10) of the treated dogs were infected with D. caninum (p < 0.0031). Through its efficacy against fleas, NexGard Spectra® treatment provided indirect prevention of D. caninum infestation. No treatment-related adverse events were ...Continue Reading

References

Jan 1, 1985·Zeitschrift Für Parasitenkunde·R E Pugh, D E Moorhouse
Jan 1, 1997·Annual Review of Entomology·M K Rust, M W Dryden
May 26, 2012·Trends in Parasitology·Frédéric Beugnet, Michel Franc
Jan 8, 2014·Parasites & Vectors·Tad B Coles, Michael W Dryden
Mar 26, 2014·Trends in Parasitology·Lénaïg HalosRichard Wall
Aug 26, 2014·Parasite : Journal De La Société Française De Parasitologie·Frédéric BeugnetJosephus Fourie

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Citations

Sep 19, 2018·The American Journal of Tropical Medicine and Hygiene·Jeba Jesudoss ChelladuraiMatthew T Brewer
Feb 13, 2020·Parasitology·Sarah G H Sapp, Richard S Bradbury
Oct 3, 2020·Insects·Michael K Rust
Oct 9, 2020·ChemMedChem·Gulshan Kumar, Ravi Shankar
Feb 4, 2021·The Journal of Parasitology·Luis Eliezer Cruz-BacabOswaldo M Torres-Chable

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Methods Mentioned

BETA
PCR

Software Mentioned

SAS
NexGard Spectra
NexGard

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