Preventive Efficacy of Tenofovir/Emtricitabine Against Severe Acute Respiratory Syndrome Coronavirus 2 Among Pre-Exposure Prophylaxis Users.

Open Forum Infectious Diseases
Oskar AyerdiSandoval Study Group

Abstract

The preventive effect that tenofovir/emtricitabine (FTC) could have against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human immunodeficiency virus-negative people is unknown. The objective of this study was to analyze the seroprevalence and clinical manifestations of COVID-19 among users of pre-exposure prophylaxis (PrEP), disoproxil fumarate/FTC (TDF/FTC), or tenofovir alafenamide (TAF)/FTC and to compare it to that of a control group. An observational descriptive study of the seroprevalence of antibodies for SARS-CoV-2 among men who have sex with men and transgender women without use of PrEP (Group 1; n = 250) and PrEP users with TDF/FTC (n = 409) or TAF/FTC (n = 91) (Group 2; n = 500) was conducted from May11, 2020 to June 27, 2020. All participants were provided with a structured questionnaire that collected information on the variables to be analyzed, and testing for immunoglobulin G antibodies to SARS-CoV-2 (chemiluminescent microparticle immunoassay) was then carried out. The seroprevalence of SARS-CoV-2 was 9.2% (95% confidence interval [CI], 5.9-13.5) in the group without PrEP and 15.0% (95% CI, 12.0-18.4) in the group with PrEP (P = .026). Among users of TDF/FTC it was 14.7% (95% CI, 11.4-18.5), ...Continue Reading

References

Apr 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jesper MelchjorsenMartin Tolstrup
Mar 13, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jose R Castillo-MancillaPeter L Anderson
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael W TraegerMark A Stoové
Jan 31, 2020·JAMA : the Journal of the American Medical Association·Alexandra L PhelanLawrence O Gostin
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 7, 2020·Gastroenterology·Fei XiaoHong Shan
May 1, 2020·Journal of Clinical Microbiology·Elitza S TheelKamran Kadkhoda
May 10, 2020·Journal of Clinical Microbiology·Andrew BryanAlexander L Greninger
Jun 1, 2020·The Lancet. HIV·Pilar VizcarraUNKNOWN COVID-19 ID Team
Jun 10, 2020·Journal of Clinical Medicine·Alberto M Borobia On Behalf Of The Covid Hulp Working Group
Jun 21, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A J JääskeläinenM Lappalainen
Jun 27, 2020·Annals of Internal Medicine·Julia Del AmoUNKNOWN The Spanish HIV/COVID-19 Collaboration
Jul 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolina Garcia-VidalUNKNOWN COVID19-Researchers
Jul 22, 2020·Journal of Proteome Research·Minchen ChienJingyue Ju

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Citations

Nov 21, 2020·Journal of Clinical Pharmacology·Golbarg AlavianZahra Sadat Torabi
Feb 27, 2021·Expert Opinion on Pharmacotherapy·María Del Mar GutierrezPere Domingo
Mar 19, 2021·Journal of Biomolecular Structure & Dynamics·Dennis C CopertinoDouglas F Nixon
Apr 30, 2021·The Lancet. HIV·Juan AmbrosioniUNKNOWN COVID-19 in HIV Investigators
May 1, 2021·Microorganisms·Seri JoDong Hae Shin
Jun 27, 2021·Pharmacology & Therapeutics·Yan Ling NgJustin Jang Hann Chu
Mar 13, 2021·AIDS·Colette DeJongMonica Gandhi
May 16, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vanessa SardáMonica Merçon

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