Preventive immunization of aged and juvenile non-human primates to β-amyloid.

Journal of Neuroinflammation
Julia KoflerClayton A Wiley

Abstract

Immunization against beta-amyloid (Aβ) is a promising approach for the treatment of Alzheimer's disease, but the optimal timing for the vaccination remains to be determined. Preventive immunization approaches may be more efficacious and associated with fewer side-effects; however, there is only limited information available from primate models about the effects of preclinical vaccination on brain amyloid composition and the neuroinflammatory milieu. Ten non-human primates (NHP) of advanced age (18-26 years) and eight 2-year-old juvenile NHPs were immunized at 0, 2, 6, 10 and 14 weeks with aggregated Aβ42 admixed with monophosphoryl lipid A as adjuvant, and monitored for up to 6 months. Anti-Aβ antibody levels and immune activation markers were assessed in plasma and cerebrospinal fluid samples before and at several time-points after immunization. Microglial activity was determined by [(11)C]PK11195 PET scans acquired before and after immunization, and by post-mortem immunohistochemical and real-time PCR evaluation. Aβ oligomer composition was assessed by immunoblot analysis in the frontal cortex of aged immunized and non-immunized control animals. All juvenile animals developed a strong and sustained serum anti-Aβ IgG antibody ...Continue Reading

References

Nov 1, 1996·Neurobiology of Aging·M GearingS S Mirra
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R B DeMattosD M Holtzman
Jul 28, 2001·Physics in Medicine and Biology·C TaiS R Cherry
Jan 5, 2002·Neurobiology of Aging·G DiCarloD Morgan
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary RenshawSuryaprakash Sambhara
Oct 3, 2003·Biochemical and Biophysical Research Communications·Nobuyuki KimuraYasuhiro Yoshikawa
Jun 16, 2004·Alzheimer Disease and Associated Disorders·Sam GandyEvan T Keller
May 11, 2005·Neurology·S GilmanUNKNOWN AN1792(QS-21)-201 Study Team
Jun 10, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie C PriceChester A Mathis
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica Koenigsknecht-Talboo, Gary E Landreth
Sep 16, 2005·Journal of Neurovirology·Dima A HammoudMartin G Pomper
Dec 13, 2005·The Journal of Clinical Investigation·Yona LevitesTodd E Golde
Mar 17, 2006·Nature·Sylvain LesnéKaren H Ashe
Apr 12, 2006·Archives of Neurology·Daniela GalimbertiElio Scarpini
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcel MaierCynthia A Lemere
Aug 19, 2006·Alzheimer Disease and Associated Disorders·Lv JianpingLuo Jinbiao
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fernando O MartinezAlberto Mantovani
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·James A R NicollClive Holmes
Nov 7, 2006·Journal of Neuroscience Research·Neelima B Chauhan
Feb 3, 2007·Expert Reviews in Molecular Medicine·Rania D KovaiouBeatrix Grubeck-Loebenstein
Dec 13, 2007·Immunity & Ageing : I & a·Richard AspinallSuryaprakash Sambhara
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Igor KlyubinMichael J Rowan
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Birgit WeinbergerBeatrix Grubeck-Loebenstein

❮ Previous
Next ❯

Citations

Nov 6, 2014·Chemical Communications : Chem Comm·Yanli TianChongzhao Ran
Mar 11, 2015·Expert Review of Neurotherapeutics·Henryk BarthelOsama Sabri
Feb 7, 2013·Pharmacology & Therapeutics·Elvira Valera, Eliezer Masliah
Mar 20, 2013·BioMed Research International·Charles A DownsMy N Helms
Aug 3, 2018·The Journal of Comparative Neurology·Melissa K EdlerMary Ann Raghanti
Jan 11, 2014·Expert Review of Vaccines·Sergio Rosales-MendozaLeticia Moreno-Fierros
Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mi Ran ChoiDai-Jin Kim
Apr 16, 2016·Journal of Alzheimer's Disease : JAD·Ângela RegoFrederico C Pereira
Sep 21, 2016·Journal of Molecular Neuroscience : MN·Qiao ZhaoBaian Chen
Feb 27, 2020·International Journal of Molecular Sciences·Yu-Chia KaoKuen-Jer Tsai

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ELISA
protein assay
PCR

Software Mentioned

Image J
PMOD
Primer3
GraphPad Prism

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.