PMID: 18181462Jan 10, 2008Paper

Preventive intervention for early psychosis in adolescents--the Palau Youth at Risk Project

Pacific Health Dialog
Hilda NgiralmauLisa Ord

Abstract

We have studied a total of 393 adolescents 14 to 19 years from Palau, where the lifetime morbid risk for broadly defined schizophrenia is 2.67% and cases cluster in large extended families. These Palauan adolescents included 52 offspring of a schizophrenic parent designated as "Genetically Highest Risk" or GHR+ and 61 nieces/nephews of affected sib-pairs/trios, designated "Genetically High Risk" or GHR. The remaining 280 subjects were recruited based on the results of a survey of Palauan high school students that was designed to screen for clinically HR and normal control adolescents with no close affected relatives. Among the selected high school students were 60 adolescents with one affected second or third degree relative who were designated as "Genetically Moderate Risk" (GMR). The remaining 220 subjects with no close affected relatives were designated as "Genetically Low Risk" (GLR). Based on a comprehensive clinical assessment using the K-SADS, we identified a total of 230 Palauan adolescents with early psychosis, 48 or 21% of whom had already transitioned to a DSM-IV psychotic disorder, predominantly schizophrenia. Together, the two highest genetic risk groups contributed 35% of the adolescent-onset DSM-IV psychosis case...Continue Reading

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