The immediate postexercise/physical activity period is critical for sickle cell trait (SCT) carriers and disease (SCD) patients. Exercise-related blood acidosis is known to trigger the cascade of HbS deoxygenation and polymerization, leading to red blood cell sickling and subsequent complications. Unfortunately, two facts worsen exercise-related blood acidosis during the initial postexercise period: First, blood lactate and H+ concentrations continue to increase for several minutes after exercise completion, exacerbating blood acidosis. Second, blood lactate concentration remains elevated and pH altered for 20-45 min during inactivity after intense exercise, keeping acid/base balance disturbed for a long period after exercise. Therefore, the risk of complications (including vasoocclusive crises and even sudden death) persists and even worsens several minutes after intense exercise completion in SCT carriers or SCD patients. Light physical activity following intense exercise (namely, active recovery) may, by accelerating lactate removal and acid/base balance restoration, reduce the risk of complications. Scientific evidence suggests that light exercise at or below the first lactate threshold is an appropriate strategy.
Lactate exchange and removal abilities in sickle cell patients and in untrained and trained healthy humans
Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise
Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait
Cardiopulmonary and gas exchange responses to acute strenuous exercise at 1,270 meters in sickle cell trait
Cardio-pulmonary responses and gas exchange during exercise in adults with homozygous sickle-cell disease (sickle-cell anaemia)
Splanchnic blood flow and hepatic glucose production in exercising humans: role of renin-angiotensin system
Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
Effects of progressive and maximal exercise on plasma levels of adhesion molecules in athletes with sickle cell trait with or without alpha-thalassemia
Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease
Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension
Functional capacity in children and young adults with sickle cell disease undergoing evaluation for cardiopulmonary disease
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle
High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer
Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia
Bone blood flow and metabolism in humans: effect of muscular exercise and other physiological perturbations
Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia.
Evidence for a profound remodeling of skeletal muscle and its microvasculature in sickle cell anemia
Reduced fitness and abnormal cardiopulmonary responses to maximal exercise testing in children and young adults with sickle cell anemia
Muscle MCT4 Content Is Correlated with the Lactate Removal Ability during Recovery Following All-Out Supramaximal Exercise in Highly-Trained Rowers
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients
Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice
Beneficial effects of endurance exercise training on skeletal muscle microvasculature in sickle cell disease patients.
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
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