Preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE): study protocol for a randomized controlled trial

Trials
Sophia M van der HoevenFrederique Paulus

Abstract

Preventive nebulization of mucolytic agents and bronchodilating drugs is a strategy aimed at the prevention of sputum plugging, and therefore atelectasis and pneumonia, in intubated and ventilated intensive care unit (ICU) patients. The present trial aims to compare a strategy using the preventive nebulization of acetylcysteine and salbutamol with nebulization on indication in intubated and ventilated ICU patients. The preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE) trial is a national multicenter open-label, two-armed, randomized controlled non-inferiority trial in the Netherlands. Nine hundred and fifty intubated and ventilated ICU patients with an anticipated duration of invasive ventilation of more than 24 hours will be randomly assigned to receive either a strategy consisting of preventive nebulization of acetylcysteine and salbutamol or a strategy consisting of nebulization of acetylcysteine and/or salbutamol on indication. The primary endpoint is the number of ventilator-free days and surviving on day 28. Secondary endpoints include ICU and hospital length of stay, ICU and hospital mortality, the occurrence of predefined pulmonary compl...Continue Reading

References

Sep 1, 1988·The American Review of Respiratory Disease·J F MurrayM R Flick
Feb 1, 1987·Pediatric Clinics of North America·R M OrtizR H Bartlett
Jan 1, 1994·Chest·F KonradM Georgieff
Oct 9, 1999·The European Respiratory Journal·E HoutmeyersM Decramer
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 18, 2000·The New England Journal of Medicine·J P KressJ B Hall
Jan 22, 2002·Critical Care Medicine·J F PayenC Jacquot
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Curtis N SesslerR K Elswick
Jun 12, 2003·JAMA : the Journal of the American Medical Association·E Wesley ElyGordon R Bernard
Jul 11, 2003·Chest·Mihai SminaConstantine A Manthous
Oct 1, 1964·Diseases of the Chest·I L BERNSTEIN, R W AUSDENMOORE
Mar 26, 2005·Anesthesiology·Michelle Duggan, Brian P Kavanagh
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Apr 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Sanja JelicPhillip Factor
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rajiv Dhand
Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey
May 23, 2012·Pharmacological Reviews·Mario CazzolaM Gabriella Matera
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Gilda PiaggioUNKNOWN CONSORT Group
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine
Mar 26, 2013·Intensive Care Medicine·Stephan EhrmannUNKNOWN REVA research network
Apr 26, 2013·Expert Opinion on Drug Delivery·James Fink, Arzu Ari
May 16, 2013·Critical Care : the Official Journal of the Critical Care Forum·Carol L HodgsonRinaldo Bellomo
May 23, 2013·JAMA : the Journal of the American Medical Association·Duncan YoungUNKNOWN TracMan Collaborators
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association

❮ Previous
Next ❯

Citations

Jul 25, 2017·Expert Review of Respiratory Medicine·Bradley L Icard, Edmundo Rubio

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02159196

Software Mentioned

ZonMW
ALEA®
TenALEA
NEBULAE
R

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.