Preventive pancreatic stents in the management of acute biliary pancreatitis (PREPAST trial): pre-study protocol for a multicenter, prospective, randomized, interventional, controlled trial

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Zsolt DubravcsikHungarian Pancreatic Study Group

Abstract

The outcome of the most common biliary form of acute pancreatitis has not changed even with the better described indications for early endoscopic intervention. It may be due to the fact that this intrevention theoretically can cause further pancreatic injury or cannot always relieve the pancreatic duct obstruction. We hypothesize that maintaining the outflow of the pancreatic duct with preventive pancreatic stents at the early ERCP improves the outcome of acute biliary pancreatitis. PREPAST is a prospective, randomized, controlled, multicenter trial. Patients with acute biliary pancreatitis with coexisting cholangitis are randomized to undergo urgent endoscopic intervention with or without pancreatic stenting within 48 h from the onset of pain, and in addition patients without signs of cholangitis but cholestasis are randomly allocated to recieve conservative treatment or early endoscopic intervention with or without pancreatic stenting within 48 h from the onset of pain. Patients without acute cholangitis and signs of cholestasis recieve conservative treatment. 230 patients are planned to be enrolled during a 48 months period from different centers. The primary endpoint is the outcome of acute biliary pancreatitis as described...Continue Reading

Associated Clinical Trials

References

Apr 16, 2005·Gut·UNKNOWN Working Party of the British Society of GastroenterologyUNKNOWN Association of Upper GI Surgeons of Great Britain and Ireland
May 9, 2007·Gastroenterology·UNKNOWN American Gastroenterological Association (AGA) Institute on "Management of Acute Pancreatits" Clinical Practice and Economic, UNKNOWN AGA Institute Governing Board
Sep 30, 2010·Gut·Péter HegyiZoltán Rakonczay
Oct 26, 2010·Endoscopy·H C van SantvoortUNKNOWN Dutch Pancreatitis Study Group
Aug 14, 2012·Gastroenterology·Anne F PeeryNicholas J Shaheen
Oct 27, 2012·Gut·Peter A BanksUNKNOWN Acute Pancreatitis Classification Working Group
Sep 27, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·UNKNOWN Working Group IAP/APA Acute Pancreatitis Guidelines

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