Preventive skin analgesia with lidocaine patch for management of post-thoracotomy pain: Results of a randomized, double blind, placebo controlled study

Thoracic Cancer
Alfonso FiorelliPasquale Sansone

Abstract

To evaluate whether pre-emptive skin analgesia using a lidocaine patch 5% would improve the effects of systemic morphine analgesia for controlling acute post-thoracotomy pain. This was a double-blind, placebo controlled, prospective study. Patients were randomly assigned to receive lidocaine 5% patch (lidocaine group) or a placebo (placebo group) three days before thoracotomy. Postoperative analgesia was induced in all cases with intravenous morphine analgesia. The intergroup differences were assessed in order to evaluate whether the lidocaine patch 5% would have effects on pain intensity when at rest and after coughing (primary end-point) on morphine consumption, on the recovery of respiratory function, and on peripheral painful pathways measured with N2 and P2 laser-evoked potential (secondary end-points). A total of 90 patients were randomized, of whom 45 were allocated to the lidocaine group and 45 to the placebo group. Lidocaine compared with the placebo group showed a significant reduction in pain intensity both at rest (P = 0.013) and after coughing (P = 0.015), and in total morphine consumption (P = 0.001); and also showed a better recovery of flow expiratory volume in one second (P = 0.025) and of forced vital capacity...Continue Reading

References

Nov 25, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R AgostinoM Manfredi
Oct 8, 2003·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci
Nov 11, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alan D L SihoeAnthony P C Yim
Oct 28, 2008·International Journal of Surgery·Alan A SaberRuvie L Martinez
May 19, 2009·Anesthesia and Analgesia·Ashraf S HabibTong J Gan
Sep 15, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alfonso FiorelliMario Santini
Aug 28, 2010·The Journal of Pain : Official Journal of the American Pain Society·Stefano TamburinGiampietro Zanette
Nov 19, 2010·Current Opinion in Anaesthesiology·Manuel Wenk, Stephan A Schug
Jun 18, 2011·The American Surgeon·Karen A ZinkMartin A Schreiber
Oct 4, 2011·Anesthesia and Analgesia·Joel KatzZe'ev Seltzer
Oct 15, 2011·British Journal of Anaesthesia·P C Thornton, D J Buggy
Oct 9, 2012·Neurophysiologie clinique = Clinical neurophysiology·M ValerianiA Truini
Jan 9, 2013·Annals of Internal Medicine·An-Wen ChanDavid Moher
Jul 24, 2014·Interactive Cardiovascular and Thoracic Surgery·Francesco Paolo CaroniaAttilio Ignazio Lo Monte
Mar 13, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alfonso FiorelliMario Santini
Nov 6, 2015·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Yu-Jen Cheng
Mar 15, 2016·The Lancet. Respiratory Medicine·Christopher CaoUNKNOWN International VATS Interest Group

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NCT02751619

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