Preventive treatment of intrauterine device-induced menstrual blood loss with tranexamic acid in Chinese women

Acta Obstetricia Et Gynecologica Scandinavica
X LinW Yuan

Abstract

To investigate whether tranexamic acid (Transamin) therapy reduces the amount of menstrual blood loss (MBL) and occurrence of menorrhagia after intrauterine device (IUD) insertion. Some 175 Chinese women attending for IUD insertion were equally assigned into 2 Transamin groups (1,000 and 500 mg, twice daily) and a placebo group. Their MBL was recorded with a pictorial chart in 3 subsequent menstrual cycles after insertion, while the MBL of 64 patients, collecting used sanitary towels, was also measured by an alkaline hematin method. A significant decline in post-insertion MBL and occurrence of menorrhagia was found in the 2 Transamin groups compared with the placebo group (p<0.05), whereas the difference in the results from the pictorial chart score was not statistically significant between the 1 g group and placebo group. Transamin treatment with a generally recommended dosage can effectively reduce the amount of IUD-induced MBL and prevent menorrhagia in Chinese women. A lower dosage than recommended (50% of recommended dosage) may have a similar preventive effect.

Citations

Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·O Graesslin, E Derniaux
Oct 28, 2011·Gynécologie, obstétrique & fertilité·H GronierG Robin
Nov 25, 2015·Obstetrics and Gynecology Clinics of North America·EmmaKate Friedlander, Bliss Kaneshiro
Sep 25, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Ahmed AlanwarE Eltaieb
Jun 18, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrTheresa A Lawrie

Related Concepts

Dose-Response Relationship, Drug
Double-Blind Method
Unmedicated IUDs
Menorrhagia
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