Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning?

Circulation
R A KlonerC P Cannon

Abstract

Ischemic preconditioning has been shown to reduce myocardial infarct size in experimental models, but its role in patients remains unclear. Angina before myocardial infarction reflects brief episodes of ischemia and may be a marker of preconditioning. As part of the Thrombolysis in Myocardial Infarction (TIMI) 4 study, we performed an analysis on the effect of a history of previous angina on in-hospital outcomes for patients with acute myocardial infarction. Patients eligible for thrombolytic therapy were enrolled into the study. Data were collected from case report forms regarding previous history of angina, in-hospital outcome and 6-week follow-up. Two hundred eighteen patients had a history of previous angina at any time before acute myocardial infarction, and 198 patients did not have previous angina. Patients with any previous history of angina were less likely than with those without angina to experience in-hospital death (3% versus 8%) (P = .03), severe congestive heart failure (CHF) or shock (1% versus 7%, P = .006), or the combined end point of in-hospital death, severe CHF, or shock (4% versus 12%, P = .004). Moreover, patients with any history of angina were more likely to have a smaller creatine kinase (CK)-determin...Continue Reading

References

Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Feb 1, 1989·Catheterization and Cardiovascular Diagnosis·J HeibigS Harris
May 1, 1988·The American Journal of Cardiology·L A PierardH E Kulbertus
Feb 1, 1987·British Heart Journal·M FujitaH Asanoi
Mar 1, 1985·Journal of the American College of Cardiology·A CortinaV Fuster
Jul 31, 1993·Lancet·D M YellonW B Pugsley

❮ Previous
Next ❯

Citations

Jul 1, 1997·Clinical Cardiology·J D Schlaifer, R A Kerensky
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J FriedmanH M Swartz
Jul 1, 1996·Molecular and Cellular Biochemistry·R StrasserW Schaper
Feb 22, 2005·Basic Research in Cardiology·Guro Valen, Jarle Vaage
Feb 3, 2007·Basic Research in Cardiology·Guro ValenJarle Vaage
Dec 31, 2005·Cardiovascular Drugs and Therapy·Richard J GuminaGarrett J Gross
May 18, 2007·Heart Failure Reviews·Shereif H Rezkalla, Robert A Kloner
Jun 25, 2005·Journal of Thrombosis and Thrombolysis·Karin Przyklenk, Peter Whittaker
Feb 18, 2010·Journal of Cardiovascular Translational Research·James A Fallavollita
Feb 1, 1996·The Annals of Thoracic Surgery·J C ClevelandA H Harken
May 1, 1996·Journal of the American College of Cardiology·P DupouyJ L Dubois-Randé
Apr 20, 2004·International Journal of Cardiology·Stavroula N PsychariDimitrios Th Kremastinos
Nov 9, 2005·International Journal of Cardiology·Jose P S HenriquesFelix Zijlstra
Mar 10, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Maike KrenzJames M Downey
May 26, 2005·Journal of Molecular and Cellular Cardiology·Andreas SkyschallyGerd Heusch
Apr 27, 2000·American Heart Journal·C B Granger
Jun 1, 1997·The American Journal of Cardiology·Y KobayashiH Nonogi
Mar 15, 1996·The American Journal of Cardiology·M MüllnerA N Laggner
Feb 24, 2001·The Annals of Thoracic Surgery·G ValenJ Vaage
Jul 5, 2003·The Annals of Thoracic Surgery·Babett BartlingAndreas Simm
May 16, 1998·The Annals of Thoracic Surgery·B S CainA H Harken
Jun 1, 1995·Journal of Molecular and Cellular Cardiology·D M WalkerD M Yellon
Jul 1, 1998·Progress in Cardiovascular Diseases·K Przyklenk, R A Kloner
Jul 7, 2000·Pharmacology & Therapeutics·A NakanoJ M Downey
Dec 9, 2003·International Journal of Cardiology·Christodoulos E PapadopoulosGeorgios E Louridas
May 18, 1999·International Journal of Cardiology·F OttaniF A Nicolini
Aug 14, 2001·Journal of the American College of Cardiology·G ValenG K Hansson
Nov 3, 2001·Journal of the American College of Cardiology·R A Kloner

❮ Previous
Next ❯