Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice; a role for the Akt signal pathway

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Hee-Seong JangKwon Moo Park

Abstract

Kidneys previously exposed to ischemia and reperfusion (I/R), pre-conditioned by I/R, are less susceptible to subsequent I/R injury. Here, we investigated the role for protein kinase B (Akt) survival signaling pathways including anti-apoptosis pathways in the reduced susceptibility of I/R-pre-conditioned kidneys. Mice were exposed to either a single I/R pre-conditioning event (SIRPC, 30 min of bilateral renal ischemia followed by 8 days of reperfusion) or sham-operation (non-SIRPC) and then subjected to either 30 min of bilateral renal ischemia or sham-operation (sham). Some of the mice received intra-peritoneal administrations of wortmannin, which is an inhibitor of phosphatidylinositol-3 kinase, PI3K. Thirty minutes of bilateral renal ischemia in non-SIRPC mice induced a dramatic increase in plasma creatinine (PCr) levels, but this was not observed in the SIRPC mouse. Consistent with the PCr results, tubular damage and apoptotic tubular cell death were more severe in the non-SIRPC mouse kidney than in the SIRPC mice. SIRPC increased the levels of phosphorylated-Akt and -Bad expression as well as the ratio of Bcl-2 to Bax expression in the kidney. I/R resulted in greater increases of phosphorylated-Akt and -Bad, Bcl-xL and Bcl...Continue Reading

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Citations

Jan 28, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudia CurciGiuseppe Grandaliano
Jun 15, 2015·Journal of the Chinese Medical Association : JCMA·Chang-Chi LaiCheng-Hsiung Huang
Oct 2, 2013·Journal of Cellular and Molecular Medicine·Massimo CollinoEmanuela Masini
Jul 5, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang Jun HanKwon Moo Park
Dec 6, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cheng-Hsiung HuangShu-Chiung Chiang
Sep 23, 2014·BioMed Research International·Hee-Seong JangKwon Moo Park
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Sep 23, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Rimda WanchooKenar D Jhaveri
Aug 30, 2018·Physiological Reports·Marc WeidenbuschHans-Joachim Anders
Nov 22, 2018·American Journal of Physiology. Renal Physiology·Suhan ZhouEn Yin Lai
Apr 18, 2019·American Journal of Physiology. Renal Physiology·Wilfred LieberthalJerrold S Levine
Aug 28, 2015·American Journal of Physiology. Renal Physiology·Pinelopi P Kapitsinou, Volker H Haase
Jul 17, 2015·American Journal of Physiology. Renal Physiology·Hee-Seong Jang, Babu J Padanilam

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