Previous studies underestimate BMAA concentrations in cycad flour

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Ran Cheng, Sandra Anne Banack

Abstract

The traditional diet of the Chamorro people of Guam has high concentrations of the neurotoxin BMAA, beta-methyl-amino-L-alanine, in cycad tortillas and from animals that feed on cycad seeds. We measured BMAA concentration in washed cycad flour and compared different extraction methods used by previous researchers in order to determine how much BMAA may have been unaccounted for in prior research. Samples were analyzed with AQC precolumn derivatization using HPLC-FD detection and verified with UPLC-UV, UPLC-MS, and triple quadrupole LC/MS/MS. Although previous workers had studied only the free amino acid component of BMAA in washed cycad flour, we detected significant levels of protein-associated BMAA in washed cycad flour. These data support a link between ALS/PDC and exposure to BMAA.

References

Jan 1, 1987·American Journal of Epidemiology·D ReedR Stallones
Aug 13, 2003·Neurology·Sandra Anne Banack, Paul Alan Cox
Aug 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susan J MurchSandra Anne Banack
Feb 7, 2006·Journal of Ethnopharmacology·Sandra Anne BanackPaul Alan Cox
Jun 13, 2006·Experimental Neurology·Shyam D RaoJohn H Weiss
Nov 14, 2006·Neurobiology of Disease·Doug LobnerRobert W Peoples
May 9, 2008·Marine Drugs·Sandra Anne BanackPaul Alan Cox

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Citations

Oct 22, 2011·International Journal of Environmental Research and Public Health·Alexander S ChiuBrett A Neilan
Aug 16, 2014·Toxicon : Official Journal of the International Society on Toxinology·Sandra Anne BanackPaul Alan Cox
Jan 23, 2016·Proceedings. Biological Sciences·Paul Alan CoxSandra Anne Banack
Jun 22, 2010·Toxicon : Official Journal of the International Society on Toxinology·S A BanackP A Cox
Nov 19, 2015·Toxicon : Official Journal of the International Society on Toxinology·Johan RosénKarl-Erik Hellenäs
Oct 16, 2015·Aquatic Toxicology·Elisabeth J FaassenMiquel Lürling
Jun 19, 2012·Journal of Mass Spectrometry : JMS·Mark W Duncan
Feb 19, 2011·Toxicon : Official Journal of the International Society on Toxinology·S A BanackP A Cox
Sep 21, 2017·Neurotoxicity Research·J S MetcalfP A Cox
May 26, 2017·Neurotoxicity Research·Paul Alan CoxGilles J Guillemin
May 10, 2017·Neurotoxicity Research·Sandra Anne Banack, Paul Alan Cox

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