PMID: 22552455May 4, 2012Paper

Previous use of quinolones: a surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Caroline DeutschendorfRodrigo Pires dos Santos

Abstract

Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV-infected patients in southern Brazil and studied the potential factors associated with resistance. We conducted a retrospective cohort study to determine the resistance profile of Mycobacterium tuberculosis isolated from HIV-infected patients and factors that could be associated with resistance from 2000 to 2005. 236 patients were included in the study. Resistance to at least one drug was observed in 32 (14.6%) isolates, and multi-drug resistance was observed in 4 (1.82%) isolates. On multivariate analysis, previous use of tuberculostatics and quinolones were related to any first-line drug resistance. In our study, previous quinolone use was significantly associated to first-line anti-TB drugs resistance. Multi-drug-resistant tuberculosis (MDR-TB) is a major problem worldwide, and we believe quinolones should be used with caution in settings where TB is endemic.

References

Aug 13, 1999·Memórias do Instituto Oswaldo Cruz·F FandinhoL Fonseca
Aug 30, 2007·The Journal of Infectious Diseases·Charles D WellsKarin Weyer
Jul 16, 2008·Annals of Internal Medicine·Woojin LewDick Menzies
Jun 3, 2009·Annals of Internal Medicine·Kai Kliiman, Alan Altraja
Jun 6, 2009·The New England Journal of Medicine·Peter R Donald, Paul D van Helden

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Citations

Sep 28, 2013·The Journal of Antimicrobial Chemotherapy·M McGrathD F Warner
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·J D FonsecaT D McHugh
May 22, 2016·Infectious Disease Clinics of North America·Richard R Watkins, Robert A Bonomo

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