Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Mads F HjorthA Astrup

Abstract

Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. Independent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P < 0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (9...Continue Reading

References

Nov 1, 1982·The American Journal of Clinical Nutrition·J A BaeckeJ E Frijters
Dec 7, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M PetersenA Astrup
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Feb 28, 2009·The New England Journal of Medicine·Frank M SacksDonald A Williamson
Nov 26, 2010·The New England Journal of Medicine·Thomas Meinert LarsenUNKNOWN Diet, Obesity, and Genes (Diogenes) Project
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
Sep 3, 2011·Science·Gary D WuJames D Lewis
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Aug 30, 2013·Nature·Aurélie CotillardStanislav Dusko Ehrlich
Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon
Nov 22, 2013·The American Journal of Clinical Nutrition·Sanne K PoulsenThomas M Larsen
Oct 10, 2014·Cell Host & Microbe·Dan KnightsRob Knight
Feb 18, 2015·The Journal of Clinical Investigation·Emeran A MayerArpana Gupta
May 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C S ByrneG Frost
Nov 11, 2015·Cell Metabolism·Petia Kovatcheva-DatcharyFredrik Bäckhed
Nov 23, 2015·Cell·David ZeeviEran Segal
Apr 14, 2016·Microbiome·Anastassia GorvitovskaiaSusan M Huse
Sep 28, 2016·The Journal of Clinical Endocrinology and Metabolism·Chao KangMantian Mi
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Mar 11, 2017·Frontiers in Cellular and Infection Microbiology·Ana C F de MoraesSandra R G Ferreira
Jun 3, 2017·Scientific Reports·Tingting ChenBruce R Hamaker
Jul 12, 2017·EBioMedicine·Arne Astrup, Mads F Hjorth
Aug 23, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Line Quist BendtsenLesli Hingstrup Larsen
Aug 26, 2017·Science·Samuel A SmitsJustin L Sonnenburg
Sep 9, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M F HjorthA Astrup

❮ Previous
Next ❯

Citations

Feb 6, 2019·Nutrients·Valentina PonzoSimona Bo
Jan 15, 2020·PloS One·Brian L FredensborgChristian M O Kapel
Jan 18, 2020·Annual Review of Food Science and Technology·Yanhui Han, Hang Xiao
May 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Roie LevyNathan D Price
Oct 1, 2020·MSystems·Avner LeshemEran Elinav
Mar 7, 2020·BMC Veterinary Research·Philippa K MorrisonCaroline McGregor Argo
Sep 6, 2020·Nature Reviews. Endocrinology·Emanuel E Canfora, Ellen E Blaak
Jul 22, 2020·Reviews in Endocrine & Metabolic Disorders·Nathalie M DelzenneAudrey M Neyrinck
Aug 10, 2020·Advances in Nutrition·Kalliopi GkouskouAristides G Eliopoulos
Dec 21, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mads F HjorthJames O Hill
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Hanieh-Sadat EjtahedBagher Larijani
Nov 30, 2018·Nutrients·Mark L Dreher
Oct 5, 2019·The Journal of Nutrition·Carmen P Ortega-Santos, Corrie M Whisner
Sep 25, 2020·Diabetes, Obesity & Metabolism·George A Bray, Donna H Ryan
Jan 26, 2021·International Journal of Food Sciences and Nutrition·Caroline N AlmadaAnderson S Sant'Ana
Feb 10, 2021·The Journal of Nutrition·Kia Nøhr Iversen, Rikard Landberg
Nov 20, 2020·Scientific Reports·Rikke Linnemann NielsenRamneek Gupta
Feb 12, 2021·Journal of Applied Microbiology·Ebenezeri Erasto NgowiDong-Dong Wu
Jan 30, 2021·The British Journal of Nutrition·Nathan V MatusheskiSzabolcs Péter
Mar 12, 2021·Advances in Nutrition·Kirsten BerdingJohn F Cryan
Mar 5, 2021·Journal of the Chinese Medical Association : JCMA·Xi-Hsuan LinFa-Yauh Lee

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01199835

Software Mentioned

STATA
SE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Mads F HjorthA Astrup
American Journal of Health Promotion : AJHP
Larry A TuckerJames D LeCheminant
The American Journal of Clinical Nutrition
Andrea C Buchholz, Dale A Schoeller
© 2022 Meta ULC. All rights reserved