Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats

Neurotoxicology and Teratology
Sherry A FergusonMerle G Paule

Abstract

At high levels of exposure, acrylamide monomer (AA) is a known neurotoxicant (LoPachin, 2004 [23]). The effects of lower levels of exposure, such as those experienced via a typical human diet, have not been widely investigated. Data at these levels are particularly relevant given the widespread human exposure through carbohydrate-containing foods cooked at high temperatures. Additionally, daily AA intake is estimated to be higher for infants and children. Earlier, we described behavioral alterations in preweaning rats resulting from developmental AA treatment (0.5-10.0mg/kg/day) (Garey et al., 2005 [14]). In the present study, the effects of lower doses were measured as well as serum AA and glycidimide (GA) levels in dams, fetuses, and young pups. Pregnant Fischer 344 dams (n=48-58/treatment group) were gavaged with 0.0, 0.1, 0.3, 1.0, or 5.0mg AA/kg/day beginning on gestational day 6 and ending on the day of parturition. Beginning on postnatal day 1 (PND 1) and continuing through PND 21, all pups/litter were gavaged with the same dose as their dam. There were no AA treatment effects on offspring fur development, pinnae detachment, or eye opening. Offspring body weight was somewhat decreased by 5.0mg/kg/day, particularly in mal...Continue Reading

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Citations

Jul 19, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·T HirvonenK Peltonen
Aug 5, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonJordan S Abshire
Jan 22, 2014·Neurotoxicology and Teratology·John J PanosSherry A Ferguson
Jul 5, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy R FennellMarvin Friedman
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Jul 21, 2020·World Journal of Gastroenterology : WJG·Elodie SarronPauline M Anton
Nov 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Katharina VejdovszkyElke Rauscher-Gabernig
Jan 20, 2021·Neurotoxicology and Teratology·Timothy J FlaniganSherry A Ferguson
Feb 10, 2019·Neurotoxicology and Teratology·Christopher L MooreSherry A Ferguson

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