PMID: 9536459Apr 16, 1998Paper

Preweaning cocaine administration alters the adult response to quipazine: comparison with fluoxetine

Neurotoxicology and Teratology
D L Dow-Edwards

Abstract

This study investigated whether exposure to cocaine during the preweaning period affects the behavioral response to administration of a challenge dose of quipazine, a relatively nonselective serotonin (5-HT) mixed agonist/antagonist, in adulthood. To determine whether selective inhibition of the 5-HT transporter during the preweaning period would produce a cocaine-like pattern of effects, another group of rats was given fluoxetine, a highly selective and potent inhibitor of the 5-HT transporter, and was tested along with the cocaine-treated rats. Male and female rats received 25 mg/kg cocaine HCl (82.5 mumol/kg), 25 mg/kg fluoxetine HCl (72.3 mumol/kg), or vehicle subcutaneous (s.c.) during postnatal days 11-20. Both treatments reduced weight gain during the injection period only. At 60 days of age, subjects were administered a single dose of quipazine (0, 0.4, or 1.0 mg/kg, s.c.) and placed in the Accuscan activity monitor for 1 h of behavioral recording. Overall, distance traveled, vertical activity, and time in the center of the chamber decreased during the initial time blocks of the session and vertical activity decreased with increasing doses of quipazine. Females in general showed greater overall activity levels than male...Continue Reading

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Citations

Sep 8, 2009·Clinics in Perinatology·Amy L SalisburyBarry M Lester
Jan 30, 2007·Neurotoxicology and Teratology·Amy L SalisburyKen Poole
Sep 29, 2004·Toxicology and Applied Pharmacology·Ruth ReevesDeborah A Cory-Slechta
Jan 5, 2010·Physiology & Behavior·Diana Dow-Edwards
Nov 1, 2003·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Susan M Melnick, Diana L Dow-Edwards
Jun 1, 1998·Annals of the New York Academy of Sciences·Diana Dow-Edwards, Yamit Busidan
Jun 12, 2018·European Journal of Pharmacology·Manuella da L D BarrosLigia Galindo

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