Preweaning food intake influences the adiposity of young adult baboons

The Journal of Clinical Investigation
D S LewisE J Masoro

Abstract

The hypothesis that preweaning nutrition influences adult fat cell number and adiposity was tested in baboons. Newborn baboons were fed Similac formulas with caloric densities of 40.5 kcal (underfed), 67.5 kcal (fed normally), and 94.5 kcal (overfed) per 100 g formula. From weaning (16 wk) until necropsy at 5 yr of age all baboons were fed the same diet. At necropsy, fat cell number and fat cell size in 10 fat depots were measured. Female baboons overfed as infants had markedly greater fat depot mass, primarily because of fat cell hypertrophy, than normally fed or underfed females. Overfed male baboons had a greater fat mass in 4 of 10 depots compared with males underfed or fed normally as infants. Underfeeding did not affect body weight, nor adipose mass of either sex. The results show that infant food intake does not have a major influence on the fat cell number of young adult baboons.

References

Jul 29, 1978·British Medical Journal·R T JungW P James
Jul 1, 1976·The New England Journal of Medicine·E CharneyR Pratt
Oct 1, 1970·Annals of Internal Medicine·G A Bray
Dec 1, 1972·The Journal of Pediatrics·J L Knittle
Nov 1, 1972·British Journal of Preventive & Social Medicine·F J MillerA M Thomson
Apr 1, 1973·The Journal of Clinical Investigation·L B SalansR E Weismann
Apr 1, 1972·British Medical Journal·C G BrookO H Wolf
Sep 1, 1968·The Journal of Clinical Investigation·J L Knittle, J Hirsch
Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith
Sep 1, 1984·American Journal of Public Health·L R ShapiroR L Huenemann
Jan 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGillG E Mott
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A H KissebahP W Adams
Apr 1, 1982·Metabolism: Clinical and Experimental·P BjörntorpP Pettersson
Mar 1, 1981·Child Development·A F Roche

❮ Previous
Next ❯

Citations

Nov 20, 2003·Nutrition·Undurti N Das
Aug 2, 2011·The Proceedings of the Nutrition Society·Mary S Fewtrell
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A B BretonB M Alexander
Jun 28, 2014·Journal of Developmental Origins of Health and Disease·H L Blackmore, S E Ozanne
Dec 16, 1998·The British Journal of Nutrition·B KoletzkoS Strobel
Nov 1, 2013·ILAR Journal·Laura A CoxJohn L VandeBerg
Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·A Lucas
Jul 23, 2004·Archives of Disease in Childhood·J B MorganM S Fewtrell
Oct 1, 1994·Archives of Disease in Childhood·A Lucas
Jan 1, 1997·Archives of Disease in Childhood·A Lucas
Jan 1, 1997·Archives of Disease in Childhood·K P Walsh
Jul 23, 1999·BMJ : British Medical Journal·A LucasT J Cole
Jun 22, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Amanda J Drake, Rebecca M Reynolds
Jan 1, 2015·Nutrients·Jessica A Grieger, Vicki L Clifton
Sep 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M NicholasI C McMillen
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Emily Oken
Jan 1, 2008·Cytokine·M E TejeroAnthony Comuzzie
Nov 24, 2007·The Journal of Pediatrics·Mandy B BelfortMatthew W Gillman
Jun 19, 2007·Obstetrics and Gynecology Clinics of North America·Peter W NathanielszPaul D Taylor
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Nov 13, 2004·Obesity Research·M Elizabeth TejeroAnthony G Comuzzie
Jan 30, 2008·Basic & Clinical Pharmacology & Toxicology·Greet SchoetersMarike Leijs
Oct 1, 1993·Metabolism: Clinical and Experimental·D S Lewis, P G Soderstrom
Apr 10, 2012·Molecular and Cellular Endocrinology·Gioia Petrighi PolidoriKevin Docherty
Jul 10, 2016·Molecular and Cellular Endocrinology·Umesh D WankhadeKartik Shankar
Apr 30, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Alan Lucas
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D S LewisH C McGill
Jan 1, 1991·Annals of the New York Academy of Sciences·G E MottH C McGill
Oct 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C Junien, P Nathanielsz
Dec 29, 2007·Journal of Pediatric Gastroenterology and Nutrition·Carlo AgostoniJohannes van Goudoever
Jan 1, 1989·American Journal of Human Biology : the Official Journal of the Human Biology Council·Anthony M Coelho, Gary W Rutenberg
Aug 25, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M E TejeroA G Comuzzie

❮ Previous
Next ❯

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