Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice.

Developmental Neuroscience
Sheryl S MoyBeverly H Koller

Abstract

Mice with knockdown of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit, encoded by the gene Grin1, have been investigated as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia. Previous work has shown that adult Grin1 mutant mice have overt deficits in habituation and sensorimotor gating, exaggerated reactivity to environmental stimuli, reduced social approach, and other alterations that reflect behavioral manifestations of schizophrenia. In humans, the emergence of overt symptoms of the disorder typically occurs in adolescence or early adulthood, suggesting a role for aberrant maturation of NMDA receptor signaling in symptom onset. The following study evaluated Grin1 mutant mice for abnormal behavioral phenotypes during the preweaning, adolescent, and adult periods. Measures included open field activity, prepulse inhibition of acoustic startle responses, and social preference in a three-chamber choice task. Mice from the C57BL/6J inbred strain, one of the parental strains for the Grin1 line, were also tested. The results showed that developmental reduction of NMDA receptor function led to significant alterations in behavior during the second and third weeks of life, including exaggerated startle re...Continue Reading

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Citations

Nov 12, 2013·Behavioural Brain Research·Lena M O'KeefeLouise D McCullough
Jan 10, 2016·Neuropharmacology·Brian L TengSheryl S Moy
Aug 18, 2012·Neurotoxicology and Teratology·Sheryl S MoyDarin J Knapp
Mar 5, 2016·Nature Reviews. Drug Discovery·Mark J MillanDaniel Weinberger
Nov 12, 2013·Behavioural Brain Research·Sheryl S MoyJames W Bodfish
Nov 14, 2019·Genes, Brain, and Behavior·Sarah L FerriEdward S Brodkin
Aug 16, 2019·International Journal of Molecular Sciences·Fabian DorningerJohannes Berger
Jun 1, 2017·NPJ Schizophrenia·Kazu NakazawaKazuhito Nakao
Mar 24, 2021·Biochemical and Biophysical Research Communications·Qingcai ChenXin Jin

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