Primary abdominal lymphonodular cryptococcosis in children: 2 case reports and a literature review

Journal of Pediatric Surgery
Chao Chun ZouZheng Yan Zhao

Abstract

Cryptococcus neoformans is an important opportunistic fungal pathogen that is acquired via the respiratory tract. It causes several clinical syndromes and most commonly presents as meningitis. The establishment of C neoformans infections in immunocompetent individuals could be owing to increased virulence, dose of the organism, or genetically determined differences in the ability to generate a protective immune response against the organism. The purpose of this study is to report on 2 case studies and a literature review and to discuss the diagnosis and management of primary abdominal lymphonodular cryptococcosis. We conducted 2 case studies and a literature review. Two cases of primary abdominal lymphonodular cryptococcosis in childhood were reported herein. The patients suffered from C neoformans without immunoglobulin or lymphocyte abnormalities. The cause of hospitalization of the 2 cases was mainly the persisting fever with or without abdominal pain. Imaging findings indicated dramatic lymphadenopathy and light hepatosplenomegaly. Excision biopsy of the abnormal lymph node demonstrated reactive lymphoid hyperplasia and the presence of C neoformans. The results of nested polymerase chain reaction confirmed the diagnosis of ...Continue Reading

References

Oct 1, 1995·American Journal of Respiratory Cell and Molecular Biology·K A HoagM F Lipscomb
Jan 1, 1997·Diagnostic Cytopathology·R DasP Ray
Aug 2, 2001·Acta Cytologica·U N SaikiaB Saikia

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Citations

Jul 27, 2010·Canadian Journal of Microbiology·José Júlio Costa SidrimMarcos Fábio Gadelha Rocha
May 28, 2011·Malawi Medical Journal : the Journal of Medical Association of Malawi·J J KumwendaS Kamiza
Oct 4, 2014·Clinical Microbiology Reviews·Sharon C-A ChenTania C Sorrell
Mar 8, 2014·The British Journal of Dermatology·K EustaceA Lally
Jun 17, 2018·Cold Spring Harbor Molecular Case Studies·Jikui GuanBengt Hallberg
Jan 17, 2012·Mycopathologia·Bruno S AraújoLuciano Z Goldani

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