PMID: 9174550Apr 1, 1997Paper

Primary acquired sideroblastic anemia, thrombocytosis, and trisomy 8

Annals of Hematology
K Patel, P Kelsey

Abstract

Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytogenetic abnormalities in myelodysplasia are invariably associated with cytopenia in one or all cell lineages. We report a patient who initially presented with slight anemia and a raised platelet count. Further investigations suggested a diagnosis of primary acquired sideroblastic anemia. Cytogenetic examination revealed a clone with trisomy 8. We believe this is the first reported case of trisomy 8 with trilineage myelodysplasia and thrombocytosis with primary acquired sideroblastic anemia.

Citations

May 27, 2004·Leukemia & Lymphoma·Alexander ClaviezCharlotte Niemeyer
Apr 3, 2012·Hematology/oncology Clinics of North America·Nanna H Sulai, Ayalew Tefferi

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