Primary afferent depolarization in the in vitro frog olfactory bulb

The Journal of Physiology
C E Jahr, R A Nicoll

Abstract

1. Experiments on the frog olfactory bulb have been performed in vitro in order to determine whether primary afferent transmission is modified by presynaptic inhibition.2. Stimulation of the olfactory nerve resulted in a prolonged depolarization of the olfactory nerve as recorded across a sucrose gap. Unstimulated olfactory nerve fibres adjacent to the stimulated fibres were also depolarized.3. An excitability increase of the olfactory nerve terminals was found that lasted the entire duration of the olfactory nerve depolarization, indicating that the terminals themselves were depolarized. Both the olfactory nerve depolarization and the excitability increase were blocked by cobalt and manganese ions.4. Low concentrations of glutamate were found to produce a substantial depolarization of the olfactory nerve. Although gamma-aminobutyric acid (GABA) also elicited a depolarization of the olfactory nerve, picrotoxin, a GABA antagonist, did not reduce the stimulus-evoked olfactory nerve depolarization.5. Recording with potassium-sensitive electrodes in the olfactory nerve terminal region demonstrated an increase in extracellular potassium with the same rise time and duration as the olfactory nerve depolarization. Cobalt and manganese ...Continue Reading

Citations

Feb 15, 1993·Microscopy Research and Technique·J Boeckh, L P Tolbert
Apr 4, 2002·Journal of Neurophysiology·Anita R GorielyLeslie P Tolbert
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matt WachowiakRainer W Friedrich
May 22, 2001·The European Journal of Neuroscience·K DelaneyW Denk
Sep 6, 2002·Microscopy Research and Technique·Matt WachowiakBarry W Ache
Oct 31, 1988·Neuroscience Letters·A KhayariJ L Davrainville
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd

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