PMID: 9163883May 1, 1997Paper

Primary amebic meningoencephalitis due to Naegleria fowleri in a South American tapir

Veterinary Pathology
F Lozano-AlarcónG S Visvesvara

Abstract

Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris are known to cause fatal central nervous system (CNS) disease in human beings. N. fowleri causes acute, fulminating primary amebic meningoencephalitis (PAM), which generally leads to death within 10 days. Acanthamoeba spp. and B. mandrillaris cause chronic granulomatous amebic encephalitis, which may last for 8 weeks. Acanthamoeba spp. and B. mandrillaris also cause CNS disease in animals. N. fowleri, however, has been described only in human beings. This report is the first of PAM in an animal, a South American tapir. Dry cough, lethargy, and coma developed in the animal, and its condition progressed to death. At necropsy, lesions were seen in the cerebrum, cerebellum, and lungs. The CNS had severe, suppurative meningoencephalitis with many neutrophils, fibrin, plasma cells, and amebas. Amebas were 6.5 microns to 9 microns in diameter and had a nucleus containing a large nucleolus. Amebas in the sections reacted with a monoclonal antibody specific for N. fowleri in the immunofluorescent assay and appeared bright green.

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Citations

Jun 2, 2011·Journal of the American Veterinary Medical Association·Marc KentScott J Schatzberg
Nov 30, 2005·The Journal of Eukaryotic Microbiology·Govinda S VisvesvaraFrederick L Schuster
Oct 18, 2003·The Journal of Eukaryotic Microbiology·Frederick L SchusterGovinda S Visvesvara
Mar 17, 2016·Parasite : Journal De La Société Française De Parasitologie·Mohamed Seghir BenterkiMichel Pélandakis
Dec 21, 2012·Integrative Zoology·Paulo Rogerio ManginiRenata Carolina Fernandes-Santos
Nov 30, 2004·Veterinary Parasitology·Frederick L Schuster, Govinda S Visvesvara
Apr 28, 2006·Veterinary Parasitology·Juan A MoralesJ P Dubey
Jan 31, 2012·Research in Veterinary Science·Luciano A PimentelFranklin Riet-Correa
Apr 13, 2007·FEMS Immunology and Medical Microbiology·Govinda S VisvesvaraFrederick L Schuster
Feb 16, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Barbara M DaftMichael D Manzer
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hailu KindeGovinda S Visvesvara
Jun 13, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Luan Cleber HenkerSaulo Petinatti Pavarini
Jul 2, 2019·Journal of the American Veterinary Medical Association·Taylor J YawJ Scot Estep

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