PMID: 8608183Nov 1, 1995Paper

Primary amino-terminal heterobifunctional poly(ethylene oxide). Facile synthesis of poly(ethylene oxide) with a primary amino group at one end and a hydroxyl group at the other end

Bioconjugate Chemistry
Y NagasakiK Kataoka

Abstract

Well-defined poly(ethylene oxide) (PEO) with a cyano group at one end and a hydroxyl group at the other terminus was synthesized by the anionic ring opening polymerization of ethylene oxide (EO) initiated with (cyanomethyl)potassium (CMP) which was prepared by the metalation reaction of acetonitrile with potassium naphthalene in THF. Primary amino-terminal heterotelechelic PEO was obtained by the reduction of the cyano group at the end of the polymer chain by lithium aluminum hydride.

Citations

Feb 26, 2004·Biomaterials·Yoshihisa KanedaTadanori Mayumi
Mar 17, 2001·Advanced Drug Delivery Reviews·K KataokaY Nagasaki
Mar 12, 2003·Advanced Drug Delivery Reviews·Hidenori OtsukaKazunori Kataoka
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geneviève GaucherJean-Christophe Leroux
Sep 21, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tadahito TakahashiYukio Nagasaki
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroko ShibataYasuo Tsutsumi
Feb 6, 2008·Biomacromolecules·M L VadalaJ S Riffle
Mar 12, 2009·Bioconjugate Chemistry·Zhongyu Li, Ying Chau
Oct 26, 2007·Bioconjugate Chemistry·Shigehiro Hiki, Kazunori Kataoka

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