Abstract
The incidence of syphilis is on the rise, particularly in male patients who are human immunodeficiency virus (HIV) positive, and men who have sex with men. To describe 4 cases of primary syphilis presenting in the anal canal to increase awareness of its presentation and morphology in this location, as the diagnosis can be easily overlooked clinically and by the pathologist. Design .- Clinical presentation, hematoxylin-eosin-stained sections, and Treponema pallidum immunohistochemical staining were reviewed in detail in all 4 cases. Three patients presented with anal canal ulcers; one presented with an ulcerated anal mass. All 4 patients were male, of whom 2 were HIV positive. Syphilis was clinically suspected in only 1 case; in 2 cases, confirmatory evaluation and treatment were prompted by pathologic diagnosis. In the fourth case, syphilis was diagnosed serologically at time of biopsy; however, the patient had an anal mass, and malignancy was clinically suspected. All 4 cases had bandlike chronic plasma cell-rich inflammation at the squamous epithelium and lamina propria junction; 2 cases had poorly formed granulomas. One case had concomitant rectal biopsy specimens with proctitis. Treponema pallidum immunohistochemistry highl...Continue Reading
References
Dec 1, 1991·Yonsei Medical Journal·W S LeeJ B Lee
Apr 1, 1993·Genitourinary Medicine·H J EngelkensE Stolz
Sep 6, 2000·International Journal of Dermatology·R G PhelpsM Saruk
Aug 28, 2004·Journal of Cutaneous Pathology·Mai P HoangKyle H Molberg
Jan 2, 2007·Current Opinion in Infectious Diseases·Thomas A Peterman, Bruce W Furness
Apr 28, 2007·American Journal of Public Health·James D HeffelfingerHillard S Weinstock
Jun 8, 2007·The Journal of Investigative Dermatology·Marc BuffetNicolas Dupin
Sep 19, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Pascale Quatresooz, Gérald E Piérard
Sep 25, 2009·Dermatology : International Journal for Clinical and Investigative Dermatology·Pascale Quatresooz, Gérald E Piérard
May 31, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Kensuke Adachi
Aug 4, 2011·Annals of Internal Medicine·John R SuHillard S Weinstock
Jul 1, 2009·Indian Journal of Sexually Transmitted Diseases and AIDS·D J DeshpandeR S Dhurat
Dec 3, 2011·The Journal of Clinical Investigation·Emily L Ho, Sheila A Lukehart
Mar 16, 2012·International Journal of Dermatology·Inge PutriJacob O Levitt
Jun 7, 2012·Chest·Saadah AlrajabSonglin Zhang
Aug 22, 2012·BMJ Open·Ajith P WeerakoonMarcus Y Chen
Oct 26, 2012·The American Journal of Surgical Pathology·Christina A ArnoldLysandra Voltaggio
May 8, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Li-Li LiuTian-Ci Yang
Jun 13, 2014·The American Journal of Surgical Pathology·Catherine E HagenJoseph Misdraji
Citations
Jun 8, 2017·Journal of Medical Microbiology·Sophie EdouardDidier Raoult
Oct 27, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Hong YouHyo Jin Park
Jul 27, 2018·BMC Musculoskeletal Disorders·Xiao LiangPeixiong Liang
Dec 12, 2018·Khirurgiia·A A UlyanovE V Kuznetsova
Dec 7, 2018·Journal of Surgical Case Reports·Daniel R A CoxEric Ee
Dec 11, 2021·The American Journal of Dermatopathology·Jérémy SchoelinckAnne Jouret-Mourin