Primary and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: an update

Cancer Investigation
Ayodele AyoolaChandra P Belani

Abstract

Epidermal growth factor receptor (EGFR) is a critical target in the treatment of nonsmall cell lung cancer (NSCLC). The mutations involving EGFR are more prevalent in patients of Asian ancestry, women, never smokers, and those with adenocarcinoma histology. Primary mechanism of resistance to EGFR-TKIs includes in frame insertion mutation in exon 20, de novo T790M mutation also on exon 20, activating mutations in KRAS, loss of PTEN, and amplification of c-MET whereas acquired resistance results from development of secondary alteration in ATP domain of T790M. There are many novel targeting agents in development to overcome resistance to EGFR TKIs.

References

Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jun 28, 2001·Oncogene·J Mendelsohn, J Baselga
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Aug 19, 2003·Nature Reviews. Molecular Cell Biology·Stefan GrünertHartmut Beug
Sep 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takeshi SuzukiToyoaki Hida
Dec 4, 2003·Current Opinion in Cell Biology·Jean Paul Thiery
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amir OnnRoy S Herbst
Feb 26, 2004·Seminars in Oncology·Fred R Hirsch, Corey J Langer
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstDavid H Johnson
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sae-Won HanNoe Kyeong Kim
Feb 25, 2005·The New England Journal of Medicine·Susumu KobayashiBalázs Halmos
Feb 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey A EngelmanLewis C Cantley
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eunice L KwakDaniel A Haber
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshimi TakanoTomohide Tamura
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 27, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstUNKNOWN TRIBUTE Investigator Group
Jul 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Todd A CarterDavid J Lockhart
Aug 27, 2005·Oncogene·Jiri Zavadil, Erwin P Böttinger
Sep 29, 2005·PLoS Medicine·Heidi GreulichMatthew Meyerson
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daphne W BellDaniel A Haber
Dec 6, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jian-Min TangXiu-Jun Chang
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David M JackmanPasi A Jänne
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Ami Citri, Yosef Yarden
Aug 1, 2006·Molecular Cancer Research : MCR·Christopher D ColdrenPaul A Bunn
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marissa N BalakWilliam Pao
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyWilliam Pao
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulrich GatzemeierJoachim Von Pawel

❮ Previous
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Citations

Mar 14, 2014·PloS One·Siang Hui LimHong Boon Lee
Feb 21, 2013·International Journal of Medical Sciences·Alberto AntonicelliAndré Emanuel Dutly
Nov 26, 2013·Biomarkers in Medicine·Daniel J O'ShannessyElizabeth B Somers
Jan 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Min ShiXu-E Li
Oct 28, 2014·Expert Opinion on Drug Safety·Mauricio BurottoGeraldine O'Sullivan Coyne
Sep 24, 2013·Clinical Therapeutics·John R Goffin, Kevin Zbuk
Dec 21, 2012·Chemical Biology & Drug Design·Joseph J Provost, Mark A Wallert
Jul 17, 2014·Journal of Proteome Research·Alfonso Martín-BernabéSandrine Bourgoin-Voillard
Mar 1, 2015·Personalized Medicine·Meagan B MyersBarbara L Parsons
Feb 3, 2015·Cancer Treatment Reviews·Carolina BizamaJuan Carlos Roa
Jun 16, 2016·Scientific Reports·Annkathrin HanssenHarriet Wikman
May 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena I PentsovaMichael F Berger
Jun 22, 2019·Expert Review of Vaccines·Yoshiro NakaharaTetsuro Sasada
Jun 19, 2013·Expert Review of Anticancer Therapy·Patrick M Forde, David S Ettinger
Feb 10, 2018·Oncology Letters·Hio Teng CheongChi Hang Wong
Feb 28, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard BourgonYulei Wang

❮ Previous
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