Primary and recurrent retroperitoneal soft tissue sarcoma: prognostic factors affecting survival

Journal of Surgical Oncology
Antonio ChiappaBruno Andreoni

Abstract

To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). An aggressive surgical approach in both primary and recurren...Continue Reading

References

Aug 1, 1991·The British Journal of Surgery·J C AlvarengaJ M Thomas
Jul 1, 1990·Annals of Surgery·D P JaquesM F Brennan
Jan 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J KinsellaS A Rosenberg
Mar 15, 1988·Cancer·R N NambisanT J Dougherty
Jun 1, 1988·World Journal of Surgery·S I HajduM F Brennan
Sep 1, 1986·Journal of the Medical Association of Georgia·J Duttenhaver
Mar 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A PotterS A Rosenberg
Aug 1, 1984·Annals of Surgery·P C McGrathG A Parker
Jun 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J E TepperP McNulty
Oct 1, 1995·Archives of Surgery·C P KarakousisD L Driscoll
Jul 1, 1993·Journal of Surgical Oncology·E ShiloniH R Freund
Aug 1, 1994·The British Journal of Surgery·M E PitcherJ M Thomas
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·D A FeinL R Coia
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·J M RobertsonT S Lawrence
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·C N CattonV Fornasier
Dec 1, 1993·Archives of Surgery·S G MarcusJ C Yang
May 1, 1996·Journal of Surgical Oncology·E BussièresB Nguyen Bui
Dec 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C P KarakousisD L Driscoll
Mar 1, 1996·Annals of Surgical Oncology·C P KarakousisD L Driscoll
Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M P JenkinsJ M Thomas
Jul 27, 1999·Surgical Oncology·K Herman, T Kusy
Nov 26, 1999·Advances in Surgery·J J Lewis, M F Brennan
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·K M AlektiarL B Harrison
Sep 15, 2000·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A HoosM F Brennan
Oct 5, 2001·Journal of the American College of Surgeons·D ShibataM F Brennan
Apr 13, 2002·Journal of the American College of Surgeons·Alexander StojadinovicMurray F Brennan
Jun 12, 2002·Current Treatment Options in Oncology·F C EilberF R Eilber
Jul 4, 2002·Annals of Surgical Oncology·Peter W T PistersShreyaskumar R Patel
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clemens-M WendtnerRolf D Issels
Dec 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurent GilbeauBinh Nguyen Bui

❮ Previous
Next ❯

Citations

Mar 13, 2012·Langenbeck's Archives of Surgery·Alexandra M KoenigMaximilian Bockhorn
Feb 11, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A H ChoiJ A Kim
Jul 7, 2007·Neurosurgical Focus·Kurtus DaffordDavid Kline
Jul 5, 2011·Journal of the American College of Surgeons·Edmund Bartlett, Sam S Yoon
Oct 27, 2009·Journal of Pediatric Surgery·Fariba NavidSheri L Spunt
Aug 25, 2016·Annals of Surgical Oncology·Trevor D HamiltonCarol J Swallow
Sep 13, 2016·Journal of Vascular and Interventional Radiology : JVIR·Wen-Zhe FanJia-Ping Li
Feb 10, 2007·Expert Review of Anticancer Therapy·Matthew H G KatzRaphael E Pollock
Sep 21, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Saveria TropeaMarco Rastrelli
Sep 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A H ChoiJ A Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Th van Dalen Dutch Soft Tissue Sarcoma Group
Journal of the American College of Surgeons
Stephen R GrobmyerMartin J Heslin
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sheri L Spunt, A S Pappo
© 2022 Meta ULC. All rights reserved